Versatile Poly(3,4-ethylenedioxythiophene) Polyelectrolytes for Bioelectronics by Incorporation of an Activated Ester
Versatile Poly(3,4-ethylenedioxythiophene) Polyelectrolytes for Bioelectronics by Incorporation of an Activated Ester
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DOI：
10.1021/acs.chemmater.2c02315
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发表时间：
2022-12
影响因子：
8.6
通讯作者：
J. Tropp;A. Mehta;Xudong Ji;Abhijith Surendran;Ruiheng Wu;Emily A. Schafer;M. M. Reddy-M.;S. P. Patel-S.
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文献类型：
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作者：
J. Tropp;A. Mehta;Xudong Ji;Abhijith Surendran;Ruiheng Wu;Emily A. Schafer;M. M. Reddy-M.;S. P. Patel-S.
生物电子学领域利用合成材料的光电特性与生命系统进行交互。这些应用要求材料具有导电性、可水处理性、生物相容性，并且可以进行化学修饰以实现生物功能化。虽然共轭聚合物和聚电解质已经被报道显示出这些特性，但同时提供这些特性的材料是罕见的。在这里，我们开发了阴离子聚电解质聚（4-（2,3-二氢噻吩[3,4-b]-[1,4]二恶英-2-酰基甲氧基）-1-丁磺酸钠盐）（PEDOT-S）的共聚物，其结构单元含有胺反应性的en -羟基琥珀酰亚胺(NHS)-酯。报道的PEDOT-NHS共聚物具有与先前报道的PEDOT-S相似的水溶性和导电性，并且能够结合重要的富含胺的生物材料。此外，PEDOT-NHS共聚物具有生物相容性和血液相容性，因此有望应用于下一代生物电子和再生工程。
The field of bioelectronics leverages the optoelectronic properties of synthetic materials to interface with living systems. These applications require materials that are conductive, aqueous-processible, biocompatible, and can be chemically modified for biofunctionalization. While conjugated polymers and polyelectrolytes have been reported that demonstrate several of these features, materials that offer each of these properties simultaneously are rare. Here, we develop copolymers of anionic polyelectrolyte poly(4-(2,3-dihydrothieno [3,4-b]-[1,4]dioxin-2-yl-methoxy)-1-butanesulfonic acid, sodium salt) (PEDOT-S) containing structural units with amine-reactiveN-hydroxysuccinimide (NHS)-esters. The reported PEDOT-NHS copolymers demonstrate water solubility and electrical conductivities similar to previously reported PEDOT-S, as well as the ability to bind important amine-rich biomaterials. Furthermore, the PEDOT-NHS copolymers were biocompatible and hemocompatible and therefore show promise for next-generation bioelectronic and regenerative engineering applications.