How Does Whisky Lower Serum Urate Level?
How Does Whisky Lower Serum Urate Level?
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DOI：
10.1002/ptr.5063
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发表时间：
2014-05
影响因子：
7.2
通讯作者：
Yang Lu;T. Nakanishi;M. Fukazawa;I. Tamai
中科院分区：
文献类型：
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作者：
Yang Lu;T. Nakanishi;M. Fukazawa;I. Tamai
临床研究表明，适量饮用威士忌会增加肾脏将尿酸盐排泄到尿液中，并降低血清尿酸盐水平，但其机制尚未确定。由于肾脏重吸收影响血清尿酸盐水平，因此检查了威士忌同系物对参与尿酸盐重吸收转运的尿酸盐转运蛋白、尿酸盐转运蛋白 1 (URAT1) 和电压驱动尿酸盐转运蛋白 (URATv1) 的影响。在表达转运蛋白的非洲爪蟾卵母细胞中，12 年和 18 年威士忌同源物抑制 URAT1 的尿酸盐摄取，IC50 值分别为 0.08 ± 0.01 和 0.04 ± 0.01 mg/mL，而 URATv1 的尿酸盐摄取仅在 1 mg/mL 时受到抑制。饮用威士忌后血清尿酸水平降低可能主要是由于同源物对 URAT1 的抑制。版权所有 © 2013 约翰·威利父子有限公司
Clinical studies have shown that moderate whisky consumption increased renal excretion of urate into urine and decreased serum urate level, but the mechanism involved has not been established. Because renal reabsorption influences serum urate level, the effects of the whisky congeners on urate transporters, urate transporter 1 (URAT1), and voltage‐driven urate transporter (URATv1) involved in reabsorptive transport of urate were examined. In transporter‐expressing Xenopus oocytes, 12‐year‐old and 18‐year‐old whisky congeners inhibited urate uptake by URAT1 with IC50 values of 0.08 ± 0.01 and 0.04 ± 0.01 mg/mL, respectively, while urate uptake by URATv1 was inhibited only at 1 mg/mL. Decreased serum urate level after whisky consumption may be mainly due to inhibition of URAT1 by the congeners. Copyright © 2013 John Wiley & Sons, Ltd.