Common susceptibility and transmission pattern of human leukocyte antigen DRB1-DQB1 haplotypes to Korean and Caucasian patients with type 1 diabetes.
Common susceptibility and transmission pattern of human leukocyte antigen DRB1-DQB1 haplotypes to Korean and Caucasian patients with type 1 diabetes.
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DOI：
10.1210/jcem.85.12.7024
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发表时间：
2000-12
期刊：
影响因子：
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通讯作者：
Y. Park;J. She;C. Y. Wang;H. Lee;S. Babu;H. Erlich;J. Noble;G. Eisenbarth
中科院分区：
文献类型：
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作者：
Y. Park;J. She;C. Y. Wang;H. Lee;S. Babu;H. Erlich;J. Noble;G. Eisenbarth
韩国1型糖尿病的发病率不到美国的1/10，并且已经提出与糖尿病相关的亚洲患者的人类白细胞抗原（HLA）等位基因不同于高加索人的等位基因。在这项研究中，我们分析了一系列HLA DRB 1-DQB 1单倍型对韩国和高加索1型糖尿病患者的常见易感性和传播模式。我们对158例1型糖尿病患者、140例来自同一地区的非糖尿病患者、49个来自首尔的单纯家系和283个来自人类生物学数据交换的家系进行了HLA DR和DQ分型。虽然两个群体的单倍型频率有很大差异，但当比较相同的单倍型时，它们的优势比几乎相同。对于所有亲本单倍型，韩国人和高加索人家族的糖尿病后代的遗传相似（r = 0.8; P：< 10（-）（4））。考虑到由于DRB 1和DQB 1单倍型的不同频率（连锁不平衡）而导致的等位基因关联的种族差异，这些数据不仅通过病例对照比较而且通过单倍型的传播分析显示，DRB 1-DQB 1单倍型的易感性效应在韩国人和高加索人中是一致的。因此，II类易感性和耐药等位基因的影响似乎超越了1型糖尿病的种族和地理多样性。
The incidence of type 1 diabetes in Korea is less than 1/10th of that in the United States, and it has been suggested that human leukocyte antigen (HLA) alleles of Asian patients associated with diabetes differ from those of Caucasians. In this study we analyzed the common susceptibility and transmission pattern of a series of HLA DRB1-DQB1 haplotypes to Korean and Caucasian patients with type 1 diabetes. We performed HLA DR and DQ typing of 158 type 1 diabetic patients in a case control study, 140 nondiabetic subjects from the same geographical area, 49 simplex families from Seoul, and 283 families from the Human Biological Data Interchange. Although the haplotype frequencies in the two populations are quite different, when identical haplotypes are compared, their odds ratios are nearly the same. For all parental haplotypes, the transmission to diabetic offspring was similar for Korean and Caucasian families (r = 0.8; P: < 10(-)(4)). Allowing for ethnic differences in allelic associations due to different frequencies of DRB1 and DQB1 haplotypes (linkage disequilibrium), these data show, not only by case-control comparison but also by transmission analyses of the haplotypes, that the susceptibility effects of DRB1-DQB1 haplotypes are consistent in Koreans and Caucasians. Thus, the influence of class II susceptibility and resistance alleles appears to transcend ethnic and geographic diversity of type 1 diabetes.