Cardiac propagation simulation.
Cardiac propagation simulation.
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DOI：
10.1201/9781003068136-17
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发表时间：
1992
影响因子：
--
通讯作者：
A. Pollard;N. Hooke;C. Henriquez
中科院分区：
文献类型：
--
作者：
A. Pollard;N. Hooke;C. Henriquez
我们已经完成了一系列基于膜的心室心肌二维和三维模型中动作电位传播的模拟。二维模拟包括心肌的双域表示，它明确地表征了细胞内、间质和细胞外空间中的组成体积导体。通过这些模拟，我们研究了细胞外体积导体在去极化过程中对跨壁心肌传播的贡献。我们还使用二维双域模拟来研究间质体积导体在具有标称和极端组织电导率的平面心肌去极化设置中的效果。我们的三维模拟包括心肌的单域表示，其将三个分量体积导体表征为单个集总导体。通过这些模拟，我们检查了纤维轴的壁内旋转对激活时间和模式的影响。为了实现实际的解决时间，我们扩展了以前报告中的数值技术，并开发了一系列适用于此类问题的新技术。去偏振波前的模拟使用快速钠电流的非线性 Ebihara 和 Johnson 膜方程作为膜模型。完整动作电位循环的模拟将 Ebihara 和 Johnson 快速钠电流与 Beeler 和 Reuter 膜方程相结合。我们的结果表明，单个体积导体和纤维轴的旋转对心室心肌模型中的电激活具有独特且可识别的影响。
We have completed a range of membrane-based simulations of action potential propagation in two- and three-dimensional models of ventricular myocardium. The two-dimensional simulations included a bidomain representation of the myocardium which explicitly characterized the component volume conductors in the intracellular, interstitial, and extracellular spaces. With these simulations, we studied the contribution of the extracellular volume conductor to transmural myocardial propagation during depolarization. We also used two-dimensional bidomain simulations to study the effect of the interstitial volume conductor in the setting of planar myocardial depolarization with nominal and extreme tissue conductivities. Our three-dimensional simulations included a monodomain representation of the myocardium which characterized the three component volume conductors as a single lumped conductor. With these simulations, we examined the effects of the intramural rotation of the fiber axes on the timing and pattern of activation. To achieve practical solution times, we extended numerical techniques from previous reports and developed a range of new techniques applicable to this class of problems. Simulations of the depolarization wavefront used the nonlinear Ebihara and Johnson membrane equations for the fast sodium current as the membrane model. Simulations of the full action potential cycle combined the Ebihara and Johnson fast sodium current with the Beeler and Reuter membrane equations. Our results demonstrated that the individual volume conductors and the rotation of fiber axes have unique and identifiable consequences on the electrical activation in models of ventricular myocardium.