HETEROGENEITY OF HUMAN PLATELETS .2. FUNCTIONAL EVIDENCE SUGGESTIVE OF YOUNG AND OLD PLATELETS
HETEROGENEITY OF HUMAN PLATELETS .2. FUNCTIONAL EVIDENCE SUGGESTIVE OF YOUNG AND OLD PLATELETS
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DOI：
10.1172/jci106064
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发表时间：
1969-01-01
影响因子：
15.9
通讯作者：
KARPATKI.S
中科院分区：
文献类型：
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作者：
KARPATKI.S
在之前的交流中，提出了大-重血小板是“年轻”血小板和轻-小血小板是“老”血小板的暗示性证据。比较大-重、轻-小和总血小板群的血小板功能。在加入二磷酸腺苷（ADP）、凝血酶或肾上腺素后，大-重血小板的血小板聚集时间比轻-小血小板短3.0倍、4.5倍和3.3倍，大-重血小板向培养基中释放的三磷酸腺苷（ATP）分别比轻-小血小板多3.7倍、7.6倍和8.1倍。凝血酶或肾上腺素聚集血小板后，大-重血小板向培养基中释放的ADP比轻-小血小板多6.0倍和3.8倍。经ADP聚集血小板后，轻、小血小板消耗的细胞外ADP比大、重血小板多5.9倍。经ADP、凝血酶或肾上腺素聚集的大-重血小板释放的血小板因子4比同样处理的轻-小血小板多9.1倍、8.5倍和12.7倍。
In the previous communication, suggestive evidence was presented for large-heavy platelets being “young” platelets and light-small platelets being “old” platelets. Large-heavy, light-small, and total human platelet populations were compared with respect to their platelet function. After addition of adenosine diphosphate (ADP), thrombin, or epinephrine, platelet aggregation time was 3.0-, 4.5-, and 3.3-fold shorter with large-heavy platelets compared with light-small platelets, and large-heavy platelets released 3.7-, 7.6-, and 8.1-fold greater adenosine triphosphate (ATP) into the medium, respectively, than did light-small platelets. After platelet aggregation by thrombin or epinephrine, large-heavy platelets released 6.0- and 3.8-fold more ADP into the medium than did light-small platelets. After platelet aggregation by ADP, light-small platelets consumed 5.9-fold greater added extracellular ADP than did large-heavy platelets.Large-heavy platelets aggregated by ADP, thrombin, or epinephrine released 9.1-, 8.5-, and 12.7-fold greater platelet factor 4 than light-small platelets similarly treated.