Differences in Collagen Metabolism between Normal and Osteoarthritic Human Articular Cartilage
Differences in Collagen Metabolism between Normal and Osteoarthritic Human Articular Cartilage
复制标题
正常和骨关节炎人类关节软骨之间胶原代谢的差异
作者：
M. Nimni;K. Deshmukh
正常人关节软骨仅合成一种α链，其表现出鸡和牛软骨所描述的αl（II）链的色谱行为。另一方面，骨关节炎软骨还合成含有α2链和β组分的胶原蛋白。这两种类型胶原的不同结构特征可能解释了骨关节炎软骨的某些功能缺陷。
Normal human articular cartilage synthesizes only one type of a chain, which exhibits the chromatographic behavior of the αl(II) chains described for chick and bovine cartilage. Osteoarthritic cartilage, on the other hand, synthesizes in addition a collagen containing α2 chains and β components. The different structural features of the two types of collagen may account for some of the functional defects of osteoarthritic cartilage.