Assessment of acridine orange and SYTO 16 for in vivo imaging of the peritoneal tissues in mice.
Assessment of acridine orange and SYTO 16 for in vivo imaging of the peritoneal tissues in mice.
复制标题
吖啶橙和 SYTO 16 对小鼠腹膜组织体内成像的评估。
DOI：
10.1111/j.1365-2818.2009.03153.x
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发表时间：
2009
影响因子：
2
通讯作者：
Gmitro,AF
中科院分区：
文献类型：
--
作者：
Udovich,JA;Besselsen,DG;Gmitro,AF
研究了小鼠腹腔注射吖啶橙和SYTO 16的作用。用这些染料染色的腹膜组织图像，并通过共聚焦显微内窥镜获得。75只Balb/c小鼠分为五组，分别腹腔注射染料或生理盐水。采用置信区间和Fisher精确统计检验比较各组阴性结果的比例。未观察到注射染料引起的不良事件有统计学意义的增加。这些数据为吖啶橙和SYTO 16用于活体成像的安全性提供了初步调查。
The effect of peritoneal injection of acridine orange and SYTO 16 in mice was investigated. Images of peritoneal tissues stained with these dyes and obtained through a confocal micro‐endoscope are presented. Seventy‐five Balb/c mice were split into five groups and given peritoneal injections of dye or saline. The proportions of negative outcomes in each group were compared using confidence intervals and the Fisher's exact statistical test. A statistically significant increase in adverse events due to dye injection was not observed. These data provide an initial investigation into the safety of acridine orange and SYTO 16 forin vivoimaging.