A highly active 4-siloxyproline catalyst for asymmetric synthesis
A highly active 4-siloxyproline catalyst for asymmetric synthesis
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DOI：
10.1002/adsc.200404166
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发表时间：
2004-10-01
影响因子：
5.4
通讯作者：
Koshino, H
中科院分区：
文献类型：
--
作者：
Hayashi, Y;Yamaguchi, J;Koshino, H
反式-4-叔丁基二甲基甲硅烷氧基-L-脯氨酸表现出比母体脯氨酸更高的催化活性而不损害对映选择性，这拓宽了羰基化合物的α-氨氧基化以及O-亚硝基醛醇/Michael和Mannich反应的底物范围。
trans-4-tert-Butyldimethylsiloxy-L-proline displays a greater catalytic activity than the parent proline without compromising the enantioselectivity, which widens the substrate scope in the alpha-aminoxylation of carbonyl compounds, as well as O-nitrosoaldol/Michael, and Mannich reactions.