Expedited palladium-catalyzed amination of aryl nonaflates through the use of microwave-irradiation and soluble organic amine bases.
Expedited palladium-catalyzed amination of aryl nonaflates through the use of microwave-irradiation and soluble organic amine bases.
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DOI：
10.1021/jo052131u
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发表时间：
2006-01
期刊：
影响因子：
--
通讯作者：
Rachel E. Tundel;K. Anderson;S. Buchwald
中科院分区：
文献类型：
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作者：
Rachel E. Tundel;K. Anderson;S. Buchwald
微波辅助下，钯催化的C-N键形成反应与芳基/杂芳基非氟化物和胺使用可溶性胺碱DBU（1,8-二氮杂环[5.4.0]十一-7-烯）或MTBD（7-甲基-1,5,7-三氮杂环[4.4.0]十二-5-烯）和配体（1-3）在短反应时间（1-45分钟）内产生良好的芳胺收率（71-99%）。
[reaction: see text] Microwave-assisted, palladium-catalyzed C-N bond-forming reactions with aryl/heteroaryl nonaflates and amines using the soluble amine bases DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) or MTBD (7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene) and ligands (1-3) resulted in good to excellent yields (71-99%) of arylamines in short reaction times (1-45 min).