Noradrenergic terminal short-term potentiation enables modality-selective integration of sensory input and vigilance state.
Noradrenergic terminal short-term potentiation enables modality-selective integration of sensory input and vigilance state.
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DOI：
10.1126/sciadv.abk1378
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发表时间：
2021-12-17
期刊：
影响因子：
13.6
通讯作者：
Paukert M
中科院分区：
文献类型：
--
作者：
Gray SR;Ye L;Ye JY;Paukert M
中间神经元和去甲肾上腺素能神经末梢之间的感觉驱动的串扰传递神经调制的模态选择性。近年来，行为状态对感觉加工和注意力的重要性得到了令人信服的证明。唤醒在控制全脑神经活动模式中起主导作用，特别是通过去甲肾上腺素的调节。包括蓝斑在内的脑干去甲肾上腺素能核团可被多种感觉刺激激活，并通过轴突投射向整个大脑传播调节信号。这种组织结构可能表明，在高度警惕的状态下，全脑去甲肾上腺素的释放是成比例的。然而，在这里，我们发现，低强度，nonarousing视觉刺激增强警觉依赖的去甲肾上腺素能信号局部在视觉皮层，显示使用双站点纤维光度监测去甲肾上腺素能钙反应的星形胶质细胞同时在小脑和视觉皮层和双光子显微镜监测去甲肾上腺素能轴突终末钙动力学。在神经元型一氧化氮合酶阳性中间神经元中N-甲基-d-天冬氨酸受体激活后，一氧化氮介导了去甲肾上腺素依赖性星形胶质细胞Ca 2+激活的短暂加速。这些发现揭示了一个候选人的皮层微电路的感觉模态选择性调制的注意。
Sensory-driven cross-talk between interneurons and noradrenergic terminals conveys modality selectivity to neural modulation. Recent years have seen compelling demonstrations of the importance of behavioral state on sensory processing and attention. Arousal plays a dominant role in controlling brain-wide neural activity patterns, particularly through modulation by norepinephrine. Noradrenergic brainstem nuclei, including locus coeruleus, can be activated by stimuli of multiple sensory modalities and broadcast modulatory signals via axonal projections throughout the brain. This organization might suggest proportional brain-wide norepinephrine release during states of heightened vigilance. Here, however, we have found that low-intensity, nonarousing visual stimuli enhanced vigilance-dependent noradrenergic signaling locally in visual cortex, revealed using dual-site fiber photometry to monitor noradrenergic Ca2+ responses of astroglia simultaneously in cerebellum and visual cortex and two-photon microscopy to monitor noradrenergic axonal terminal Ca2+ dynamics. Nitric oxide, following N-methyl-d-aspartate receptor activation in neuronal nitric oxide synthase-positive interneurons, mediated transient acceleration of norepinephrine-dependent astroglia Ca2+ activation. These findings reveal a candidate cortical microcircuit for sensory modality-selective modulation of attention.