One-pot syntheses of 2,3-dihydrothiopyran-4-one derivatives by Pd/Cu-catalyzed reactions of α,β-unsaturated thioesters with propargyl alcohols
One-pot syntheses of 2,3-dihydrothiopyran-4-one derivatives by Pd/Cu-catalyzed reactions of α,β-unsaturated thioesters with propargyl alcohols
复制标题
DOI：
10.1021/ol800754w
复制
发表时间：
2008-06-19
期刊：
影响因子：
5.2
通讯作者：
Kambe, Nobuaki
中科院分区：
文献类型：
--
作者：
Minami, Yasunori;Kuniyasu, Hitoshi;Kambe, Nobuaki
在Pd/Cu催化下，α，β-不饱和硫酯与炔丙醇在碱存在下反应，制备了2，3-二氢噻喃-4-酮衍生物。值得注意的是，由于单一程序，两个碳-硫键都被裂解。
2,3-Dihydrothiopyran-4-one derivatives were readily prepared by Pd/Cu-catalyzed reactions between alpha,beta-unsaturated thioesters and propargyl alcohols in the presence of bases. Of note, both carbon-sulfur bonds were cleaved as a result of the single procedure.