Prevalence of and Risk Factors for Peripheral Neuropathy in Chinese Patients With Diabetes: A Multicenter Cross-Sectional Study.
Prevalence of and Risk Factors for Peripheral Neuropathy in Chinese Patients With Diabetes: A Multicenter Cross-Sectional Study.
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中国糖尿病患者周围神经病变的患病率和危险因素：一项多中心横断面研究
DOI：
10.3389/fendo.2018.00617
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发表时间：
2018
影响因子：
5.2
通讯作者：
Guo L
中科院分区：
文献类型：
--
作者：
Pan Q;Li Q;Deng W;Zhao D;Qi L;Huang W;Ma L;Li H;Li Y;Lyu X;Wang A;Yao H;Xing X;Guo L
糖尿病周围神经病变(DPN)是糖尿病最常见的并发症，其进展严重影响患者的生活质量。本研究调查了北京地区1型和2型糖尿病患者中DPN的患病率和危险因素，并比较了各种诊断方法的优劣。通过问卷调查和检查，对来自北京13个中心的2048名糖尿病患者进行了DPN评估。将患者分为DPN组和可疑DPN/非DPN组。比较两组的人口学、临床和生物学特征。采用二元Logistic回归分析确定与糖尿病患者DPN相关的潜在变量。并对各种诊断方法进行了比较。在2048例糖尿病患者中，1型糖尿病73例，2型糖尿病1,975例。其中714例(34.86%)诊断为DPN，537例(26.22%)怀疑为DPN，797例(38.92%)诊断为无DPN。在2型糖尿病患者中，患者的年龄、糖尿病病程和糖尿病视网膜病变是DPN的显著独立危险因素。OR值分别为1.439(95%可信区间：1.282~1.616，P<0.001)、1.297(95%可信区间：1.151~1.462，P<0.001)、0.637(95%可信区间：0.506~0.802，P<0.01)。踝关节反射、温度感觉加振动感觉是1型和2型糖尿病患者最好的筛查试验。优登指数分别为62.2%和69.8%。北京地区1型和2型糖尿病患者DPN患病率分别为21.92%和35.34%。患者年龄、糖尿病病程、糖尿病视网膜病变是DPN的独立危险因素。
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, and its progression significantly worsens the patient's quality of life. This study investigated the prevalence and risk factors associated with DPN in a large sample of Beijing individuals with type 1 and 2 diabetes, as well as compared the diagnostic methods for DPN. A total of 2,048 diabetic patients from 13 centers in Beijing were assessed for DPN through questionnaires and examination. Patients were divided into DPN group and suspected DPN/non-DPN group. The demographic, clinical and biological characteristics between the two groups were compared. Binary logistic regression analysis was performed to identify potential variables associated with DPN in diabetic patients. The diagnostic methods for DPN were also compared. Among the 2,048 diabetic patients, 73 cases of type 1 diabetes mellitus, 1,975 cases of type 2 diabetes were included in this study. Among them, 714 (34.86%) were identified with DPN, 537 (26.22%) were suspected of having DPN, and 797 (38.92%) were identified without DPN. Patient's age, duration of diabetes, and diabetic retinopathy were the significant independent risk factor for DPN among patients with type 2 diabetes. The odds ratio (OR) was 1.439 (95% confidence interval (CI): 1.282–1.616, P < 0.001), 1.297 (95% CI: 1.151–1.462, P < 0.001), and 0.637 (95% CI: 0.506–0.802, P < 0.001), respectively. Ankle reflex, temperature sensation plus vibration sensation are the best screening test for patients with type 1 and 2 diabetes. The Youden indexes were 62.2 and 69.8%, respectively. The prevalence rates of DPN in the Chinese patients with type 1 and type 2 diabetes in Beijing were 21.92 and 35.34%, respectively. Patient's age, duration of diabetes, and diabetic retinopathy are the independent risk factors for DPN.