IMMUNITY IN CHILDREN WITH EXPOSURE TO ENVIRONMENTAL LEAD .2. EFFECTS ON HUMORAL IMMUNITY
IMMUNITY IN CHILDREN WITH EXPOSURE TO ENVIRONMENTAL LEAD .2. EFFECTS ON HUMORAL IMMUNITY
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DOI：
10.1007/bf01747914
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发表时间：
1994-12-01
影响因子：
4.2
通讯作者：
BENGSCH, H
中科院分区：
文献类型：
--
作者：
LUTZ, PM;BAUER, S;BENGSCH, H
在动物研究中发现，铅会抑制免疫系统，其水平远低于造成明显毒性的水平。 动物系统的文献研究最清楚地表明，铅对特定免疫原性刺激的反应的影响。 关于铅对六岁以下儿童免疫系统影响的数据很少。 I期研究的这一部分报告了IgG、IgM、伊加和IgE的浓度，以及针对白喉、破伤风和风疹疫苗提供的特异性抗原刺激的抗体滴度。 研究人群包括一组193名儿童，年龄9个月至6岁，谁参加了WIC（妇女，婴儿和儿童）和铅中毒预防计划在斯普林菲尔德格林县密苏里州的城市地区。 血铅水平从1到50 mug dL-1不等。 测定总lg水平并分析数据。 在所研究的五个年龄组的风险类别之间没有观察到一致的显著差异。 三个年龄组中的每一个的单个lg类别在不同的危险类别中显示出明显的显著差异，但这些差异与血铅无关。 对白喉、破伤风和风疹的特异性抗体滴度进行分析。 本研究第一阶段现有数据的回归分析表明，铅对白喉和风疹抗体滴度有不利影响。
Lead has been found to depress the immune system in animal studies at levels far below those responsible for overt toxicity. Literature studies in animal systems most clearly showed an effect of lead on response to a specific immunogenic stimulus. Data are sparse concerning the effects of lead on the immune system in the human population at greatest risk for exposure-children up to six years of age. This portion of the Phase I study reports concentrations of IgG, IgM, IgA, and IgE, as well as antibody titers to the specific antigenic stimuli provided by the vaccines against diphtheria, tetanus, and Rubella. The study population consisted of a group of 193 children, ages 9 months to 6 years, who participate in the WIC (Women, Infants and Children) and Lead Poisoning Prevention Programs in the urban area of Springfield-Greene County Missouri. Blood lead levels ranged from 1 to 50 mug dL-1. Total lg levels were determined and the data were analysed. No consistent significant differences were observed among the risk categories in the five age groups examined. A single lg class in each of three age groups showed apparent significant differences among the various risk categories, but these differences were not correlated with blood lead. An analysis of specific antibody titers to diphtheria, tetanus, and Rubella was performed. Regression analyses of current data in Phase I of this study suggest a detrimental effect of lead on the antibody titres to diphtheria and Rubella.