Differentiation of the Mammary Epithelial Cell during Involution: Implications for Breast Cancer
Differentiation of the Mammary Epithelial Cell during Involution: Implications for Breast Cancer
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DOI：
10.1007/s10911-009-9121-0
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发表时间：
2009-06-01
影响因子：
2.5
通讯作者：
Henson, Peter M.
中科院分区：
文献类型：
--
作者：
Monks, Jenifer;Henson, Peter M.
乳汁分泌不是乳腺肺泡细胞的最终分化状态，这是一个相对较新的概念。最近的工作表明，分泌，乳腺上皮细胞（MEC）有另一个功能，以执行之前，他们经历细胞死亡在退化的乳腺。也就是说，它们有助于最终清除和分解邻近的细胞（可能还有残留的乳汁）。它们会在短时间内变成业余吞噬细胞，或称巨噬细胞，然后被认为会死亡并自行清除。虽然相对较少的研究已经取得了这种变化的功能状态的MEC，然而，我们可以推测从退化的文献，并从其他系统的凋亡细胞清除，一些相关的机制扩展的结果。随着退化可能代表转移性乳腺癌进展的独特易感性窗口的发现，我们也可能建议沿着这些路线进行未来的研究。
That milk secretion is not the final differentiated state of the mammary alveolar cells is a relatively new concept. Recent work has suggested that secreting, mammary epithelial cells (MECs) have another function to perform before they undergo cell death in the involuting mammary gland. That is, they help in the final clearance and breakdown of their neighboring cells (and likely residual milk as well.) They become, for a short time, amateur phagocytes, or efferocytes, and then are believed to die and be cleared themselves. Although relatively little study has been made of this change in the functional state of the MEC, nevertheless we may speculate from the involution literature, and extend findings from other systems of apoptotic cell clearance, on some of the mechanisms involved. And with the finding that involution may represent a unique susceptibility window for the progression of metastatic breast cancer, we may suggest areas for future research along these lines as well.