SELF-ADMINISTRATION OF METHYLENEDIOXYMETHAMPHETAMINE (MDMA) BY RHESUS-MONKEYS
SELF-ADMINISTRATION OF METHYLENEDIOXYMETHAMPHETAMINE (MDMA) BY RHESUS-MONKEYS
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DOI：
10.1016/0376-8716(86)90047-5
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发表时间：
1986-10-01
影响因子：
4.2
通讯作者：
HARRIS, LS
中科院分区：
文献类型：
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作者：
BEARDSLEY, PM;BALSTER, RL;HARRIS, LS
在每天1小时的时间段内，用盐水和（1 - 3，4-亚甲二氧基甲基苯丙胺）（MDMA;每次输注3-300 μ g/kg）测试四只被训练按下用于静脉内可卡因输注的杠杆的恒河猴。在基线期间，可卡因输注量是盐水输注量的四倍到九倍多。当用MDMA代替可卡因时，4只猴子中有3只自我给药至少一次，给药速率超过生理盐水输注的范围。事实上，其中两只猴子自我注射MDMA的速度比可卡因更快。这些结果表明，MDMA可以作为恒河猴的阳性兴奋剂，并与其他临床前行为研究一起，表明人类娱乐性使用MDMA的潜力。
Four rhesus monkeys trained to press levers for intravenous cocaine infusions were tested with saline and (]-3,4-methylenedioxymethamphetamine (MDMA; 3-300 .mu.g/kg per infusion) during daily 1-h sessions. From four to over nine times more cocaine infusions were obtained than saline infusions during baseline sessions. When MDMA was substituted for cocaine, at least one dose was self-administered in 3 of the 4 monkeys at rates that exceeded the range of saline infusions. In fact, two of the monkeys self-administered a dose of MDMA at a greater rate than cocaine. These results demonstrate that MDMA can serve as a positive reinforcer for rhesus monkeys and, taken together with other preclinical behavioral studies, suggest a potential for recreational use of MDMA by humans.