Adenoid cystic carcinoma of the head and neck: Clinicopathologic analysis of 218 cases in a Chinese population
Adenoid cystic carcinoma of the head and neck: Clinicopathologic analysis of 218 cases in a Chinese population
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DOI：
10.1016/j.oooo.2012.11.018
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发表时间：
2013-03-01
影响因子：
2.9
通讯作者：
Li, Jiang
中科院分区：
文献类型：
--
作者：
Zhang, Chun-Ye;Xia, Rong-Hui;Li, Jiang
目标。本研究旨在分析头颈腺样囊性癌(ACCHN)的临床病理特征和预后因素。本文对218例ACCHN患者进行了回顾性研究。队列包括110名男性和108名女性；腮腺和腭部是最常见的受累部位。在203名有随访资料(2-132个月)的患者中，57人死于肿瘤。远处转移83例(40.9%)，局部复发34例(16.7%)。Cox回归分析表明，可靠的模式是LR的标志，切缘阳性和年龄较大是DM的危险因素。组织学类型、T分期、N分期、LR、DM和患者年龄有助于疾病特异性生存的预测。在中国ACCHN患者预后不良的预测因素中，可靠的类型、转移、LR和高龄是最重要的因素。(《口腔外科》《口腔医学》《口腔病理》《口腔放射学》2013；115：368-375)
Objective. The aim of this study was to analyze the clinicopathologic characteristics and prognostic factors of adenoid cystic carcinoma of the head and neck (ACCHN).Study Design. This was a retrospective study of 218 patients with ACCHN.Results. The cohort included 110 men and 108 women; the parotid and the palate were the most common site of involvement. Of 203 patients with follow-up information (range 2-132 months), 57 had died of the tumor. Distant metastasis (DM) and local recurrence (LR) were documented in 83 (40.9%) and 34 (16.7%) patients, respectively. Cox regression analysis indicated that a solid pattern was a marker for LR and that positive margins and older age were risk factors for DM. Histologic pattern, T stage, N stage, LR, DM, and patient age contributed to the prediction of disease-specific survival.Conclusions. A solid pattern, metastasis, LR, and older age are the most important factors for predicting poor prognosis in Chinese patients with ACCHN. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:368-375)