Changes of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic demyelinating optic neuritis and neuromyelitis optica.
Changes of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic demyelinating optic neuritis and neuromyelitis optica.
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DOI：
10.1016/j.jneuroim.2014.12.004
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发表时间：
2015-02-15
影响因子：
3.3
通讯作者：
Shihui, Wei
中科院分区：
文献类型：
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作者：
Tingjun, Chen;Zhaohui, Li;Shihui, Wei
CXC趋化因子（CXC基序配体12和CXC基序配体14）和血小板衍生生长因子被认为在许多脱髓鞘疾病的过程中调节髓鞘再生。本研究通过使用酶联免疫吸附试验测量其在脑脊液中的浓度，比较了特发性脱髓鞘性视神经炎（IDON）和视神经肌炎（NMO）患者脑中这些趋化因子水平的差异。我们的数据表明，神经炎的预后取决于髓鞘再生过程，由于减少趋化因子受损。低得多的趋化因子水平将特别表明严重的神经炎，如NMO。
The CXC chemokines (CXC-motif ligand 12 and CXC-motif ligand 14) and platelet-derived growth factor are suggested to modulate remyelination in the course of many demyelinating diseases. The present study compared the difference in the brain levels of these chemokines between patients with idiopathic demyelinating optic neuritis (IDON) and neuromyelitis optica (NMO) by measuring their concentrations in the cerebrospinal fluid using an enzyme linked immunosorbent assay. Our data indicate that the prognosis of neuritis depends on the remyelinating process that is impaired due to decreased chemokines. The much lower levels of chemokines would specifically indicate the severe neuritis, such as NMO.