Water chlorination and birth defects
Water chlorination and birth defects
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DOI：
10.1097/00001648-199909000-00008
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发表时间：
1999-09-01
期刊：
影响因子：
5.4
通讯作者：
Dybing, E
中科院分区：
文献类型：
--
作者：
Magnus, P;Jaakkola, JJK;Dybing, E
含有有机化合物的饮用水的氯化会导致副产物的形成，其中一些已被证明具有诱变或致癌作用。到目前为止，人们对可能对人类胎儿产生的致畸作用知之甚少。我们将挪威水务登记处与1993-1995年医学出生登记处联系起来，该登记处载有1994年关于氯化做法和颜色(天然有机物的指标)的数据。计算了每个市镇接触氯化消毒的人口比例和饮用水中的加权平均色数。在141,077名新生儿中，有2,608名(1.8%)有出生缺陷，在暴露组(高色；氯化)和对照组(低色；无氯化)之间的比较中，调整后的优势比为1.14(0.99-1.31)，1.26(0.61-2.62)，和1.99(1.10-3.57)。这项研究进一步证明，在一个氯化副产物水平相对较低的国家，腐植酸水的氯化作用是导致出生缺陷的潜在原因。
Chlorination of drinking water that contains organic compounds leads to the formation of by products, some of which have been shown to have mutagenic or carcinogenic effects. As yet, too little is known about the possible teratogenic effects on the human fetus. We linked the Norwegian waterwork registry, containing 1994 data on chlorination practice and color (an indicator for natural organic matter), with the Medical Birth Registry for 1993-1995. The proportion of the population exposed to chlorination and a weighted mean color number in drinking water was computed for each municipality. Among 141,077 births, 2,608 (1.8%) had birth defects, In a comparison between exposed (high color; chlorination) and reference groups (low color; no chlorination), the adjusted odds ratio was 1.14 (0.99-1.31) for any malformation, 1.26 (0.61-2.62) for neural tube defects, and 1.99 (1.10-3.57) for urinary tract defects. This study provides further evidence of the role of chlorination of humic water as a potential cause of birth defects, in a country with relatively low levels of chlorination byproducts.