NAN-190 potentiates the circadian response to light and speeds re-entrainment to advanced light cycles.
NAN-190 potentiates the circadian response to light and speeds re-entrainment to advanced light cycles.
复制标题
NAN-190 增强对光的昼夜节律反应，并加速重新进入高级光周期。
DOI：
10.1016/j.neuroscience.2008.04.054
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发表时间：
2008
期刊：
影响因子：
3.3
通讯作者：
Harrington,ME
中科院分区：
文献类型：
--
作者：
Kessler,EJ;Sprouse,J;Harrington,ME
健康问题可能源于外部环境和内源性昼夜节律之间的不同步，但昼夜节律系统无法快速适应外部日常周期中的大的突然变化。在这项研究中，我们研究了NAN-190增强光的昼夜节律反应的能力，如通过行为活动节律的阶段所测量的。NAN-190（5mg/kg，i.p.）能够显着增强适应黑暗的仓鼠和携带的仓鼠对光线的反应。此外，NAN-190即使在光照后6小时内给药也有效。对光脉冲的反应在幅度上更大，并且涉及更少的不稳定瞬态周期。最后，当与媒介物处理的动物相比时，NAN-190能够将再夹带加速至光/暗循环的6小时提前平均6天。这项工作表明，像NAN-190这样的化合物可能具有巨大的潜力，可以作为时差，轮班工作和其他昼夜节律紊乱的药物治疗。
Health problems can arise from de-synchrony between the external environment and the endogenous circadian rhythm, yet the circadian system is not able to quickly adjust to large, abrupt changes in the external daily cycle. In this study, we investigated the ability of NAN-190 to potentiate the circadian rhythm response to light as measured by phase of behavioral activity rhythms. NAN-190 (5 mg/kg, i.p.) was able to significantly potentiate the response to light both in dark-adapted and entrained hamsters. Furthermore, NAN-190 was effective even when administered up to 6 h after light onset. Response to a light pulse was both greater in magnitude and involved fewer unstable transient cycles. Finally, NAN-190 was able to speed re-entrainment to a 6 h advance of the light/dark cycle by an average of 6 days when compared with vehicle-treated animals. This work suggests that compounds like NAN-190 may hold great potential as a pharmaceutical treatment for jetlag, shift work, and other circadian disorders.