Collective biodosimetry as a dosimetric "gold standard": a study of three radiation accidents.
Collective biodosimetry as a dosimetric "gold standard": a study of three radiation accidents.
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集体生物剂量测定作为剂量测定“金标准”：对三起辐射事故的研究。
DOI：
10.1097/00004032-199703000-00006
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发表时间：
1997
期刊：
影响因子：
2.2
通讯作者：
R. Gale
中科院分区：
文献类型：
--
作者：
B. Pass;A. Baranov;E. D. Kleshchenko;J. Aldrich;P. Scallion;R. Gale
为了确定辐射损害或负担与重要生物学结果之间的因果关系，需要对生物学相关剂量进行量化。大多数针对意外辐射暴露的流行病学研究未能确定因果关系，因为无法为暴露人群构建有效的剂量量化。没有一种生物剂量测定技术（生物物理或生物）能够满足理想剂量计的所有要求，因此有资格成为“黄金标准”。该报告将新结果与先前发布的数据相结合，旨在建立集体生物剂量测定法，作为三起辐射事故受害者的剂量测定“黄金标准”。结合新的和以前发布的数据是必要的，因为在辐射事故的初始阶段很少执行和规划全面的剂量测定。第一个对象是切尔诺贝利核事故初期的一名消防员；第二个是不明职业事故的受害者；第三个暴露于 60Co 灭菌源。用于三名事故受害者的各种生物剂量测定技术之间总体上具有良好的一致性。
Quantification of the biologically relevant dose is required for the establishment of cause-and-effect between radiation detriment or burden and important biological outcomes. Most epidemiological studies of unanticipated radiation exposure fail to establish cause and effect because of an inability to construct a valid quantification of dose for the exposed population. No one biodosimetric technique (biophysical or biological) meets all the requirements of an ideal dosimeter and thus qualify as a "gold standard." This report combines new results with previously published data in order to establish a collective biodosimetry as a dosimetric "gold standard" for the victims of three radiation accidents. Combining new and previously published data is necessary as execution and planning of a comprehensive dosimetry is rarely done at the initial stages of a radiation accident. The first subject was a fireman during the initial moments of the Chernobyl nuclear accident; the second was the victim of an unspecified occupational accident; and the third was exposed to a 60Co sterilization source. There was generally good agreement among the various biodosimetric techniques used for the three accident victims.