Adeno-endocrine cell carcinoma of the gallbladder.
Adeno-endocrine cell carcinoma of the gallbladder.
复制标题
DOI：
10.1007/s005340050161
复制
发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Hayashi, I
中科院分区：
文献类型：
--
作者：
Eriguchi, N;Aoyagi, S;Hayashi, I
我们遇到一个罕见的情况下，腺内分泌细胞癌的胆囊在一个81岁的妇女。影像学检查显示胆总管结石。行内镜下括约肌切开术，成功取出结石。此后，行胆囊切除术。在胆囊颈部发现一个乳头状肿瘤。组织学上，肿瘤包括两个组成部分，高分化腺癌和内分泌细胞癌。然而，未观察到肿瘤激素活性的临床体征。内分泌细胞癌区域的肿瘤细胞小而圆。这些肿瘤细胞的组织化学研究为嗜铬粒蛋白A和Grimelius银浸渍阳性。腺癌区域的肿瘤细胞为高分化腺癌，包括具有管状结构或实体生长模式的杯状细胞。这些腺癌细胞对阿尔新蓝和高碘酸-希夫染色呈阳性，两种类型的肿瘤细胞对碳水化合物抗原和癌胚抗原染色呈阳性。提示胆囊内分泌细胞癌的组织发生与胆囊腺癌密切相关。
We encountered a rare case of adeno-endocrine cell carcinoma of the gallbladder in an 81-year-old woman. Imaging study revealed a common bile duct stone. Endoscopic sphincterotomy was performed, and the stone was extracted successfully. Thereafter, cholecystectomy was performed. A papillary tumor was found in the neck of the gallbladder. Histologically, the tumor consisted of two components, well differentiated adenocarcinoma and endocrine cell carcinoma. However, no clinical signs of tumor hormonal activity were observed. The tumor cells in the area of the endocrine cell carcinoma were small and round. Histochemical studies of these tumor cells were positive for chromogranin A and Grimelius silver impregnation. The tumor cells in the area of the adenocarcinoma were well differentiated adenocarcinoma and included goblet-type cells with a tubular structure or solid growth pattern. These adenocarcinoma cells stained positively for Alcian blue and periodic acid-Schiff, and both types of tumor cells stained positively for carbohydrate antigen and carcinoembryonic antigen. It was suggested that the histogenesis of the endocrine cell carcinoma of the gallbladder was closely related to that of the adenocarcinoma.