Engineering, on-demand manufacturing, and scaling-up of polymeric nanocapsules
Engineering, on-demand manufacturing, and scaling-up of polymeric nanocapsules
复制标题
DOI：
10.1002/btm2.10118
复制
发表时间：
2019-01-01
影响因子：
7.4
通讯作者：
Jose Alonso, Maria
中科院分区：
文献类型：
--
作者：
Crecente-Campo, Jose;Jose Alonso, Maria
聚合物纳米胶囊是一种多功能的递送系统，具有在其油核中装载亲脂药物和在其聚合物外壳中装载亲水药物的能力。这项工作的目的是扩大技术的可能性，以制备定制的纳米胶囊。首先，我们采用溶剂置换技术在50-500 nm范围内调节所得纳米胶囊的粒径。我们还生产了由一层或多层聚合物组成的纳米系统，如壳聚糖、葡聚糖硫酸盐、透明质酸、硫酸软骨素和海藻酸盐。此外，我们确定了将该工艺转化为小型化高通量定制制造的条件，从而能够对配方进行大规模筛选。最后，纳米胶囊的生产规模在批量生产和微流体的应用中都得到了扩大。这些纳米胶囊的多功能性及其制造技术有望推动其从实验室到临床的发展。
Polymeric nanocapsules are versatile delivery systems with the capacity to load lipophilic drugs in their oily nucleus and hydrophilic drugs in their polymeric shell. The objective of this work was to expand the technological possibilities to prepare customized nanocapsules. First, we adapted the solvent displacement technique to modulate the particle size of the resulting nanocapsules in the 50-500 nm range. We also produced nanosystems with a shell made of one or multiple polymer layers i.e. chitosan, dextran sulphate, hyaluronate, chondroitin sulphate, and alginate. In addition, we identified the conditions to translate the process into a miniaturized high-throughput tailor-made fabrication that enables massive screening of formulations. Finally, the production of the nanocapsules was scaled-up both in a batch production, and also using microfluidics. The versatility of the properties of these nanocapsules and their fabrication technologies is expected to propel their advance from bench to clinic.