DIFFERENTIAL REINFORCEMENT OF ALTERNATIVE BEHAVIOR INCREASES RESISTANCE TO EXTINCTION: CLINICAL DEMONSTRATION, ANIMAL MODELING, AND CLINICAL TEST OF ONE SOLUTION
DIFFERENTIAL REINFORCEMENT OF ALTERNATIVE BEHAVIOR INCREASES RESISTANCE TO EXTINCTION: CLINICAL DEMONSTRATION, ANIMAL MODELING, AND CLINICAL TEST OF ONE SOLUTION
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DOI：
10.1901/jeab.2010.93-349
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Zangrillo, Amanda N.
中科院分区：
文献类型：
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作者：
Mace, F. Charles;McComas, Jennifer J.;Zangrillo, Amanda N.
对鸽子的行为动量的基础研究表明，替代行为的差异性强化可以增加目标行为对变化的抵抗力。这一发现表明，临床应用的神经刺激可能会无意中增加目标行为的持久性，即使它降低了其频率。我们进行了三个协调的实验，以测试是否有持续加强临床显著的目标行为的影响，然后在非人类和临床研究中测试这个问题的可能解决方案的有效性。实验1在临床研究中比较了基线强化率与更高强化率后的消退阻力。灭绝的抵抗力在灭绝后大大增强。实验2测试了一个可能解决这个问题的大鼠模型。在没有强化目标反应的情况下训练替代反应，可以规避持续强化的反应效应。实验3将大鼠模型转化为一种新的临床应用。在一个单独的背景下训练一个替代反应，导致对灭绝泰坦的抵抗力较低，灭绝泰坦在与目标行为强化相关的背景下使用了一个替代反应。讨论了协调的双向翻译研究的价值。
Basic research with pigeons on behavioral momentum suggests that differential reinforcement of alternative behavior (DRA) can increase the resistance of target behavior to change. This finding suggests that clinical applications of DRA may inadvertently increase the persistence of target behavior even as it decreases its frequency. We conducted three coordinated experiments to test whether DRA has persistence-strengthening effects on clinically significant target behavior and then tested the effectiveness of a possible solution to this problem in both a nonhuman and clinical study. Experiment, 1 compared resistance to extinction following baseline rates of reinforcement versus higher DRA rates of reinforcement in a clinical study. Resistance to extinction was substantially greater following DRA. Experiment 2 tested a rat model of a possible solution to this problem. Training an alternative response in a context without reinforcement of the target response circumvented the persistence-strengthening effects of DRA. Experiment 3 translated the rat model into a novel clinical application of DRA. Training an alternative response with DRA in a separate context resulted in lower resistance to extinction titan employing DRA in the context correlated with reinforcement of target behavior. The value of coordinated bidirectional translational research is discussed.