Contribution of Endogeus Acetylcholine to STDP Induction
Contribution of Endogeus Acetylcholine to STDP Induction
复制标题
内源乙酰胆碱对 STDP 诱导的贡献
DOI：
10.1007/978-94-017-9548-7_38
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Takeshi Aihara
中科院分区：
文献类型：
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作者：
Eriko Sugisaki;Yasuhiro Fukushima;Minoru Tsukada;Takeshi Aihara
突触的可塑性被认为在学习和记忆中起着至关重要的作用。据报道，突触前和突触后活动的相对时间决定了海马突触变化的方向和程度，称为尖峰时间依赖性可塑性（STDP）。突触前锋电位先于突触后锋电位的前后定时诱导长时程增强（LTP）。同时，胆碱能输入被认为与感觉输入相结合，在学习记忆中起重要作用。内侧隔区的胆碱能神经元投射其终末至海马CA1区释放乙酰胆碱（ACh）。为了研究内源性ACh对STDP的影响，在中间神经元激活的CA1网络下应用STDP方案的前后定时。结果表明，在艾司氯胺酮存在下，STDP增强，这种增强不仅是由锥体神经元上的毒蕈碱和烟碱激活引起的，而且也是由中间神经元上的毒蕈碱和烟碱激活引起的。这些结果表明，ACh在海马CA1区网络的突触可塑性中起着重要的调节作用。
The synaptic plasticity is thought to play a crucial role in learning and memory. It has been reported that the relative timing of pre- and postsynaptic activity determines the direction and extent of hippocampal synaptic changes known as spike-timing dependent plasticity (STDP). Pre-post timing where presynaptic spike precedes a post synaptic spike induces long-term potentiation (LTP). Meanwhile, cholinergic inputs are considered to be integrated with sensory inputs and to play an important role in learning and memory. Cholinergic neurons in the medial septum are projecting their terminals to hippocampal CA1 to release acetylcholine (ACh). In order to investigate the influence of endogenous ACh on STDP, pre-post timing of STDP protocol was applied under interneuron-activated CA1 network. As the results, STDP was enhanced in the presence of eserine, and this enhancement was induced by the muscarinic and nicotinic activation not only on pyramidal neuron but also on interneurons. These findings suggest that ACh plays a critical role as a modulator for synaptic plasticity in hippocampal CA1 network.