ABSORPTION AND TISSUE DISTRIBUTION OF CURCUMIN IN RATS
ABSORPTION AND TISSUE DISTRIBUTION OF CURCUMIN IN RATS
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DOI：
10.1016/0300-483x(80)90122-5
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发表时间：
1980-01-01
期刊：
影响因子：
4.5
通讯作者：
CHANDRASEKHARA, N
中科院分区：
文献类型：
--
作者：
RAVINDRANATH, V;CHANDRASEKHARA, N
大鼠口服400 mg姜黄素（姜黄的主要色素，一种来自姜黄的印度香料）后，约60%的剂量被吸收。尿中未检出环切肽。结合葡萄糖醛酸苷和硫酸盐的尿排泄显著增加。心脏血液中不存在姜黄素。姜黄素给药后15分钟至24小时，在门静脉血中仅观察到痕量（小于5 μ g/ml），在肝脏和肾脏中观察到可忽略的量（< 20 μ g/组织）。在24小时结束时，残留在肠道下部（盲肠和大肠）的姜黄素浓度为给药量的38%。
After oral administration of 400 mg curcumin [the major pigment of turmeric, an Indian spice from Curcuma longa] to rats, about 60% of the dose was absorbed. No circumin was detectable in urine. The urinary excretion of conjugated glucuronides and sulfates significantly increased. No curcumin was present in heart blood. Only traces (less than 5 .mu.g/ml) in portal blood and negligible quantities in liver and kidney (< 20 .mu.g/tissue) were observed from 15 min up to 24 h after curcumin administration. At the end of 24 h the concentration of curcumin remaining in the lower part of the gut (cecum and large intestine) amounted to 38% of the quantity administered.