Coadaptaition in mother and infant regulated by a paternally expressed imprinted gene
Coadaptaition in mother and infant regulated by a paternally expressed imprinted gene
复制标题
DOI：
10.1098/rspb.2004.2725
复制
发表时间：
2004-06-22
影响因子：
4.7
通讯作者：
Keverne, EB
中科院分区：
文献类型：
--
作者：
Curley, JP;Barton, S;Keverne, EB
本研究调查了父系表达的印记基因的靶向突变如何调节胎儿和产后发育的多个方面，包括胎盘大小，胎儿生长，哺乳和产后生长，断奶年龄和青春期开始。母亲中的这种相同突变会损害母亲的生殖成功，减少母亲护理，减少母亲怀孕期间的食物摄入量，并削弱牛奶的排泄，这反过来又会降低婴儿的生长，推迟断奶和青春期的开始。这些共适应性状在母亲和后代中通过相同的父系表达的印记基因同步的重要性确保了获得“良好”母亲养育的后代本身将得到良好的供应和遗传倾向于“良好”的母亲养育。
This study investigates how a targeted mutation of a paternally expressed imprinted gene regulates multiple aspects of foetal and post-natal development including placental size, foetal growth, suckling and post-natal growth, weaning age and puberty onset. This same mutation in a mother impairs maternal reproductive success with reduced maternal care, reduced maternal food intake during pregnancy, and impaired milk let-down, which in turn reduces infant growth and delays weaning and onset of puberty. The significance of these coadaptive traits being synchronized in mother and offspring by the same paternally expressed imprinted gene ensures that offspring that have extracted 'good' maternal nurturing will themselves be both well provisioned and genetically predisposed towards 'good' mothering.