Survival of children born with congenital anomalies
Survival of children born with congenital anomalies
复制标题
DOI：
10.1136/adc.88.5.391
复制
发表时间：
2003-05-01
影响因子：
5.2
通讯作者：
Stone, DH
中科院分区：
文献类型：
--
作者：
Dastgiri, S;Gilmour, WH;Stone, DH
目的：描述生存到5岁的儿童出生的先天性anteriors.Methods：在1980年和1997年之间，6153例活产先天性异常的诊断和登记的人口为基础的格拉斯哥注册的先天性异常。他们进行了回顾性随访，以评估他们的生存状态，从出生到5 years.Results的年龄：存活到第一周，第一和第五年结束的先天性畸形的所有活产婴儿的比例分别为94%，89%和88%。随访终点为5岁，染色体异常婴儿（48%）的存活率明显低于神经管缺陷（72%）、呼吸系统异常（74%）、先天性心脏病（75%）、神经系统异常（77%）和唐氏综合征（84%）。虽然几乎90%的先天性畸形活产婴儿存活至5年，但不同畸形类型之间的存活率存在显著差异。我们的研究结果应该是有用的临床医生和遗传学家，以评估先天性异常的预后。这一信息对于受影响的家庭和规划这一高危人群的保健需求也很重要。
Aim: To describe the survival to age 5 years of children born with congenital anomalies.Methods: Between 1980 and 1997, 6153 live born cases of congenital anomaly were diagnosed and registered by the population based Glasgow Register of Congenital Anomalies. They were retrospectively followed to assess their survival status from birth up to the age of 5 years.Results: The proportions of all live born infants with congenital anomalies surviving to the end of the first week, and first and fifth year were 94%, 89%, and 88%, respectively. Survival to age 5, the end point of follow up, was significantly poorer for infants with chromosomal anomalies (48%) compared to neural tube defects (72%), respiratory system anomalies (74%), congenital heart disease (75%), nervous system anomalies (77%), and Down's syndrome (84%).Conclusion: Although almost 90% of all live born infants with congenital anomalies survive to 5 years, there are notable variations in survival between anomaly types. Our findings should be useful for both clinicians and geneticists to assess the prognosis of congenital anomalies. This information is also important for affected families and for the planning of health care needs for this high risk population.