miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis
miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis
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DOI：
10.1002/1873-3468.12309
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发表时间：
2016-08-01
期刊：
影响因子：
3.5
通讯作者：
Nan, Yuemin
中科院分区：
文献类型：
--
作者：
Niu, Xuemin;Fu, Na;Nan, Yuemin
MicroRNA (miRNA) 在肝纤维化的发生发展中发挥着关键作用。然而，miRNA在丙型肝炎病毒（HCV）相关肝纤维化中的功能仍不清楚。在本研究中，我们系统分析了HCV诱导的肝纤维化患者血清miRNA的微阵列数据。在 41 个失调的 miRNA 中，miR-1273g-3p 是上调最显着的 miRNA，并且与肝纤维化的阶段相关。 miR-1273g-3p的过表达可以抑制PTEN的翻译，增加-SMA、Col1A1的表达，并减少HSC的凋亡。因此，我们得出结论，在HCV相关的肝纤维化中，miR-1273g-3p可能通过直接靶向PTEN来影响HSC的激活和凋亡。
MicroRNA (miRNA) play a pivotal role in the development of liver fibrosis. However, the functions of miRNA in hepatitis C virus (HCV)-related liver fibrosis remain unclear. In this study, we systematically analyzed the microarray data of the serum miRNA in patients with HCV-induced hepatic fibrosis. Among 41 dysregulated miRNA, miR-1273g-3p was the most significantly upregulated miRNA and correlated with the stage of liver fibrosis. Overexpression of miR-1273g-3p could inhibit translation of PTEN, increase the expression of -SMA, Col1A1, and reduce apoptosis in HSCs. Hence, we conclude that miR-1273g-3p might affect the activation and apoptosis of HSCs by directly targeting PTEN in HCV-related liver fibrosis.