A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2
A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2
复制标题
苔藓细胞回路通过 Gria2I 抑制 Gria2 控制记忆检索的功效
DOI：
10.1016/j.celrep.2021.108741
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发表时间：
2021-02-16
期刊：
影响因子：
8.8
通讯作者：
Lu, Youming
中科院分区：
文献类型：
--
作者：
Li, Xinyan;Chen, Wenting;Lu, Youming
苔藓细胞 (MC) 是海马体中一组独特的兴奋性神经元，海马体是对情绪、学习和记忆非常重要的大脑区域。由于缺乏可靠的方法将 MC 与其他细胞类型分离，因此 MC 如何整合神经信息并将其传递到突触目标以参与特定功能仍然未知。在这里，我们报告说，MC 通过直接突触到局部生长抑素表达（SST）细胞来控制空间记忆检索的功效。 MC-SST 突触传递经历长时程增强 (LTP)，需要 Gria2 缺乏 Ca2+ 可渗透的抗 α-氨基-3-羟基-5-甲基-4-异恶唑-丙酸 (AMPA) 受体 (Ca2+ AR)。长非编码 RNA (Gria21) 与 SST 细胞中的 Gria2 转录抑制因子相关。沉默 Gria2I 会诱导 Gria2 转录，阻断 MCs-SST 突触传递的 LTP，并降低记忆检索的效率。因此，MCs 直接且功能性地神经支配局部 SST 神经元，并且这种神经支配通过 Gria2I 抑制 Gria2 转录来控制空间记忆检索的功效。
Mossy cells (MCs) are a unique group of excitatory neurons in the hippocampus, a brain region important for emotion, learning, and memory. Due to the lack of a reliable method to isolate MCs from other cell types, how MCs integrate neural information and convey it to their synaptic targets for engaging a specific function are still unknown. Here, we report that MCs control the efficacy of spatial memory retrieval by synapsing directly onto local somatostatin-expressing (SST) cells. MC-SST synaptic transmission undergoes long-term potentiation (LTP), requiring Gria2-lacking Ca2+ -permeable anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (Ca2+ AR). A long noncoding RNA (Gria21) is associated with Gria2 transcriptional repressors in SST cells. Silencing Gria2I induces Gria2 transcription, blocks LTP of MCs-SST synaptic transmission, and reduces the efficacy of memory retrieval. Thus, MCs directly and functionally innervate local SST neurons, and this innervation controls the efficacy of spatial memory retrieval by Gria2I inhibition of Gria2 transcription.