International Trends in Colorectal Cancer Incidence Rates
International Trends in Colorectal Cancer Incidence Rates
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DOI：
10.1158/1055-9965.epi-09-0090
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发表时间：
2009-06-01
影响因子：
3.8
通讯作者：
Ward, Elizabeth
中科院分区：
文献类型：
--
作者：
Center, Melissa M.;Jemal, Ahmedin;Ward, Elizabeth
背景：以前的研究已经记录了结直肠癌发病率的显着差异和趋势的区域和国家之间。然而，没有研究使用来自IARC的最新更新的发病率数据来检查全球模式。研究方法：我们从五大洲癌症发病率（CI 5）数据库中的癌症登记处获得了1953-57年至1.998-2002年的性别特异性结直肠癌发病率。对51个有长期发病率数据的癌症登记中心，通过计算1998-2002年与1983- 87年的发病率比值，评估过去20年的发病率变化。从1983- 1987年到1998年，男性和女性的结直肠癌发病率在统计上都有显著增加，2002年，在分析中考虑了51个癌症登记处中的27个，主要局限于经济转型国家，包括东欧国家、亚洲大部分地区和南美洲的一些国家。这些增长在男子中比在妇女中更为显著。我们还观察到日本等国家的结直肠癌发病率趋势存在很大差异。同样，以色列和新加坡的趋势也因族裔而有很大差异。美国是唯一一个结直肠癌发病率下降的国家，在男性和females.Conclusions：结直肠癌的发病率继续增加，在经济转型国家，在捷克共和国和斯洛伐克男性的发病率超过了在美国和其他长期发达国家观察到的发病率峰值。有针对性的预防和早期发现计划可以帮助扭转这些国家的趋势。（Cancer Epidemiol Biomarkers Prev 2009;18（6）：1688-94）
Background: Previous studies have documented significant variations in colorectal cancer incidence rates and trends regionally and across countries. However, no study has examined the worldwide pattern using the most recently updated incidence data from the IARC. Methods: We obtained sex-specific colorectal cancer incidence for 1953-57 through 1.998-2002 by cancer registry from Cancer Incidence in Five Continents (CI5) databases. For 51 cancer registries with long-term incidence data, we assessed the change in the incidence rates over the past 20 years by calculating the ratio of the incidence rates in 1998-2002 to that in 1983-87.Results: Colorectal cancer incidence rates for both males and females statistically significantly increased from 1983-87 to 1998-2002 for 27 of 51 cancer registries considered in the analysis, largely confined to economically transitioning countries including Eastern European countries, most parts of Asia, and select countries of South America. These increases were more prominent for men than for women. We also observed substantial variations in colorectal cancer incidence trends within countries such as Japan. Similarly, trends in Israel and Singapore varied significantly according to ethnicity. The United States is the only country where colorectal cancer incidence rates declined in both males and females.Conclusions: Colorectal cancer incidence rates continue to increase in economically transitioning countries, with incidence rates among men in the Czech Republic and Slovakia exceeding the peak incidence observed in the United States and other long-standing developed nations. Targeted prevention and early detection programs could help reverse the trend in these countries. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1688-94)