The Mormyrid Electrosensory Lobe In Vitro: Physiology and Pharmacology of Cells and Circuits
The Mormyrid Electrosensory Lobe In Vitro: Physiology and Pharmacology of Cells and Circuits
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蛹虫草电感觉叶体外：细胞和电路的生理学和药理学
DOI：
10.1523/jneurosci.18-15-06009.1998
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
C. Bell
中科院分区：
文献类型：
--
作者：
K. Grant;Y. Sugawara;L. Gómez;Victor Z. Han;C. Bell
用离体切片法研究了金线鱼的电感觉叶（ELL）。从形态学上确定的细胞和场电位记录的细胞内记录被用来表征ELL细胞的生理学和药理学。大多数细胞内记录来自被称为中神经节细胞的浦肯野样中间神经元和两种类型的传出神经元，大神经节和大梭形细胞。初级传入纤维的刺激在这些细胞中激发兴奋和抑制作用，兴奋作用由AMPA和NMDA型谷氨酸受体介导，抑制作用由GABAA和甘氨酸受体介导。神经纤维刺激引起EPSP-IPSP序列，EPSP由AMPA和NMDA受体介导，IPSP仅由GABAA受体介导。平行纤维诱发的EPSP和IPSP显示出明显的成对脉冲易化。一个大的和异常广泛的穗记录内中神经节细胞，和场电位反应表明，这穗传播到顶端树突。这些结果为理解ELL中的外周输入和中枢输入是如何整合的提供了必要的信息。
This paper is concerned with the electrosensory lobe (ELL) of mormyrid electric fish as examined in in vitro slices. Intracellular recordings from morphologically identified cells and field potential recordings were used to characterize the physiology and pharmacology of ELL cells. Most intracellular recordings were from the Purkinje-like interneurons that are known as medium ganglion cells and from the two types of efferent neurons, large ganglion and large fusiform cells. Stimulation of primary afferent fibers elicits both excitatory and inhibitory effects in these cells, with the excitatory effects being mediated by both the AMPA and NMDA types of glutamate receptors and the inhibitory effects being mediated by both GABAA and glycine receptors. Parallel-fiber stimulation evokes an EPSP–IPSP sequence, with the EPSPs being mediated by both AMPA and NMDA receptors and the IPSPs being mediated by GABAA receptors only. The parallel fiber-evoked EPSPs and IPSPs show marked paired-pulse facilitation. A large and unusually broad spike is recorded inside medium ganglion cells, and field potential responses suggest that this spike is propagated into the apical dendrites. The results provide essential information for understanding how peripheral and central inputs are integrated in ELL.
耳蜗背核平行纤维突触处的 N-甲基-D-天冬氨酸受体。
影响因子：
2.5
作者：
Manis,PB;Molitor,SC
通讯作者：
Molitor,SC
DOI：
10.1073/pnas.87.7.2662
发表时间：
1990-04-01
影响因子：
11.1
作者：
KONNERTH, A;LLANO, I;ARMSTRONG, CM
通讯作者：
ARMSTRONG, CM