Design of a prognostic score model for nasopharyngeal carcinoma
Design of a prognostic score model for nasopharyngeal carcinoma
复制标题
鼻咽癌预后评分模型的设计
DOI：
10.1002/hed.23642
复制
发表时间：
2015-05-01
影响因子：
2.9
通讯作者：
Cai, Qing-Qing
中科院分区：
文献类型：
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作者：
Luo, Xiao-Lin;He, Wang;Cai, Qing-Qing
背景本分析的目的是建立一个前所未有的新诊断鼻咽癌（NPC）的预后评分模型。方法我们回顾性回顾了419例新诊断的、非播散性的、活检证实的鼻咽癌患者的病历。结果独立的预后因素包括年龄>45、III/IV期、Epstein-Barr病毒DNA酶特异性中和抗体（AER）抗酶率>58%、和绝对中性粒细胞计数 (ANC) >4.7 x 10(9)/L。根据预后评分模型获得四个预后组：低风险组（总分=0-2）；低中风险组（总分=3-4）；高、中危组（总分=5-6）；和高风险组（总分 = 7）。结论我们提出的预后评分模型是改善 NPC 患者预后评估、将患者分层到需要不同治疗的不同风险组以及比较临床试验的有用工具。 (c) 2014 年 Wiley 期刊公司 Head Neck37: 624-629, 2015
BackgroundThe purpose of this analysis was to create a prognostic score model for newly diagnosed nasopharyngeal carcinoma (NPC) which has not been created before.MethodsWe retrospectively reviewed the medical records of 419 patients with newly diagnosed, nondisseminated, and biopsy proven NPC.ResultsIndependent prognostic factors included age >45, stage III/IV, antienzyme rate of Epstein-Barr virus DNase-specific neutralizing antibody (AER) >58%, and absolute neutrophil count (ANC) >4.7 x 10(9)/L. Four prognostic groups based on prognostic score model were obtained: low-risk group (total score = 0-2); low-intermediate-risk group (total score = 3-4); high-intermediate-risk group (total score = 5-6); and high-risk group (total score = 7).ConclusionOur proposed prognostic score model was a useful tool for improving the prognostic assessment of patients with NPC, stratifying patients into different risk groups that call for different treatments, and comparing clinical trials. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 624-629, 2015