Encapsulation of CdSe/ZnS quantum dots in poly(ethylene glycol)-Poly(D,L-lactide) micelle for biomedical imaging and detection
Encapsulation of CdSe/ZnS quantum dots in poly(ethylene glycol)-Poly(D,L-lactide) micelle for biomedical imaging and detection
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DOI：
10.1007/bf03218795
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发表时间：
2007-06-01
影响因子：
2.4
通讯作者：
Huh, Kang Moo
中科院分区：
文献类型：
--
作者：
Lee, Yong-Kyu;Hong, Suk Min;Huh, Kang Moo
合成了在红光区发光的CdSe/Z，nS量子点，并将其封装在聚乙二醇-聚丙交酯二嵌段共聚物胶束中，制备了水溶性、生物相容性的量子点胶束。以聚乙二醇（PEG）为大分子引发剂，通过丙交酯开环聚合，合成了聚乙二醇-聚乳酸（PEG-PLA）嵌段共聚物。使用氯仿中的固体分散体方法用PEG-PLA聚合物包封QD。所得的聚合物胶束，与封装的量子点，其特征在于使用各种分析技术，如紫外-可见光谱测量，光散射，荧光光谱，透射电子显微镜（TEM）和原子力显微镜（AFM）。具有封装的QD的聚合物胶束是球形的，并且显示出在20-150 nm范围内的直径。封装的量子点具有很高的发光性，在生物医学成像和检测方面具有很高的应用潜力。
Luminescent CdSe/Z,nS QDs, with emission in the red region of the spectrum, were synthesized and encapsulated in poly(ethylene glycol)-poly(D,L-lactide) diblock copolymer micelles, to prepare water-soluble, bio-compatible QD micelles. PEG-PLA dibtock copolymers were synthesized by ring opening polymerization of D,Lactide, in the presence of methoxy PEG as a macroinitiator. QDs were encapsulated with PEG-PLA polymers using a solid dispersion method in chloroform. The resultant polymer micelles, with encapsulated QDs, were characterized using various analytical techniques, such as UV-Vis measurement, light scattering, fluorescence spectroscopy, transmission electron microscopy (TEM) and atomic forced microscopy (AFM). The polymer micelles, with encapsulated QDs, were spherical and showed diameters in the range of 20-150 nm. The encapsulated QDs were highly luminescent, and have high potential for applications in biomedical imaging and detection.