Age-related differences in the bone mineralization pattern of rats following exercise.
Age-related differences in the bone mineralization pattern of rats following exercise.
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运动后大鼠骨矿化模式与年龄相关的差异。
DOI：
10.1093/geronj/41.4.445
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Saltman,P
中科院分区：
文献类型：
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作者：
McDonald,R;Hegenauer,J;Saltman,P
在7个月、14个月和19个月大的大鼠中研究了12周跑台运动对骨小梁和皮质骨矿化的影响。通过测量股骨、肱骨、肋骨和颅骨中Ca、Mg和羟脯氨酸的浓度以及45 Ca浓度的摄取来评价骨矿化。7个月和14个月大的大鼠增加了那些直接参与运动的皮质骨的矿化。19个月的动物通过增加检查的所有骨骼中的矿化来对运动做出反应，包括非承重骨小梁颅骨和皮质肋骨。从这些数据中，很明显，与年轻动物的局部适应相比，老年动物在运动中经历了总骨骼矿化。此外，我们提供的证据，以支持使用大鼠作为模型，在其中研究哺乳动物的骨生理老化过程中。
The effect of 12 weeks of treadmill exercise on the mineralization of trabecular and cortical bone was studied in rats 7, 14, and 19 months of age. Bone mineralization was evaluated by measuring concentrations of Ca, Mg, and hydroxyproline as well as uptake of45Ca concentration in the femur, humerus, rib and calvaria. The 7-and 14-month-old rats increased mineralization in those cortical bones directly involved in exercise. The 19-month animal responded to exercise by increasing mineralization in all bones examined, including the nonweight bearing trabecular calvaria and cortical rib. From these data, it is apparent that the older animals undergo a total skeletal mineralization in response to exercise compared with local adaptation in the younger animal. Further, we provide evidence to support the use of the rat as a model in which to study mammalian bone physiology during the aging process.