Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder.
Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder.
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DOI：
10.1016/j.physbeh.2017.08.004
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发表时间：
2017-10-15
影响因子：
2.9
通讯作者：
Moran TH
中科院分区：
文献类型：
--
作者：
Chawla A;Cordner ZA;Boersma G;Moran TH
暴食症（BED）是指在短时间内反复出现的、令人痛苦的过度食用可口食物（PF）的疾病。临床研究表明，患有BED的个体可能在认知过程，执行功能，冲动控制和决策方面存在障碍，这可能在维持暴食行为中发挥作用。然而，这些临床报告是有限的，往往相互矛盾。在这项研究中，我们使用了一个有限的访问大鼠模型的暴食样行为，以进一步探讨暴食对认知的影响。在暴食倾向（BEP）大鼠中，我们发现了新的物体识别（NOR）以及巴恩斯迷宫逆转学习（BM-RL）缺陷。本实验观察了脑源性神经营养因子（BDNF）和原肌球蛋白受体激酶B（Trk B）在BEP大鼠海马-前额叶（HPC-PFC）网络中的异常表达。此外，NOR缺陷与海马CA 3区TrkB和胰岛素受体（Ir）表达的减少相关。此外，上调5-羟色胺-2C（5-HT 2C）受体在眶前额叶皮层（OFC）与BM-RL赤字。最后，在延髓核（NAc），我们发现减少多巴胺受体2（Drd 2）的表达在BEP大鼠。总而言之，这些数据表明，暴饮暴食蔬菜起酥油可能会诱发情境性和逆转性学习缺陷，这可能至少部分是由CA 3-OFC-NAc神经网络中基因表达的改变介导的。
Binge eating disorder (BED) is defined as recurrent, distressing over-consumption of palatable food (PF) in a short time period. Clinical studies suggest that individuals with BED may have impairments in cognitive processes, executive functioning, impulse control, and decision-making, which may play a role in sustaining binge eating behavior. These clinical reports, however, are limited and often conflicting. In this study, we used a limited access rat model of binge-like behavior in order to further explore the effects of binge eating on cognition. In binge eating prone (BEP) rats, we found novel object recognition (NOR) as well as Barnes maze reversal learning (BM-RL) deficits. Aberrant gene expression of brain derived neurotrophic factor (Bdnf) and tropomyosin receptor kinase B (TrkB) in the hippocampus (HPC)-prefrontal cortex (PFC) network was observed in BEP rats. Additionally, the NOR deficits were correlated with reductions in the expression of TrkB and insulin receptor (Ir) in the CA3 region of the hippocampus. Furthermore, up-regulation of serotonin-2C (5-HT2C) receptors in the orbitoprefrontal cortex (OFC) were associated with BM-RL deficit. Finally, in the nucleus accumbens (NAc), we found decreased dopamine receptor 2 (Drd2) expression among BEP rats. Taken together, these data suggest that binge eating vegetable shortening may induce contextual and reversal learning deficits which may be mediated, at least in part, by the altered expression of genes in the CA3-OFC-NAc neural network.
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影响因子：
3.4
作者：
Alsiö J;Nilsson SR;Gastambide F;Wang RA;Dam SA;Mar AC;Tricklebank M;Robbins TW
通讯作者：
Robbins TW
影响因子：
5.5
作者：
Agrawal, Rahul;Gomez-Pinilla, Fernando
通讯作者：
Gomez-Pinilla, Fernando
影响因子：
6.1
作者：
Arnold SE;Lucki I;Brookshire BR;Carlson GC;Browne CA;Kazi H;Bang S;Choi BR;Chen Y;McMullen MF;Kim SF
通讯作者：
Kim SF
DOI：
10.1523/jneurosci.1521-08.2008
发表时间：
2008-10-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clarke HF;Robbins TW;Roberts AC
通讯作者：
Roberts AC
影响因子：
4.4
作者：
Aloi M;Rania M;Caroleo M;Bruni A;Palmieri A;Cauteruccio MA;De Fazio P;Segura-García C
通讯作者：
Segura-García C