Palladium/Norbornene-Catalyzed Ortho-Acylation and Ipso-Selenation via C(O)-Se Bond Cleavage: Synthesis of α-Carbonyl Selane.
Palladium/Norbornene-Catalyzed Ortho-Acylation and Ipso-Selenation via C(O)-Se Bond Cleavage: Synthesis of α-Carbonyl Selane.
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DOI：
10.1021/acs.orglett.8b00112
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发表时间：
2018-02
期刊：
影响因子：
5.2
通讯作者：
Xiaozhong Fan;Z. Gu
中科院分区：
文献类型：
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作者：
Xiaozhong Fan;Z. Gu
提出了一种钯/降冰片烯催化合成方法，该方法结合了选择性邻位C-H键活化和顺序反应形成复杂的硒化物化合物。成功地裂解了硒酸盐中的C(O)-Se键，合成了多种α-羰基硒烷，收率较高。该反应具有良好的官能团耐受性和广泛的底物范围。
A palladium/norbornene-catalyzed synthetic method that combines selective ortho C-H bond activation with sequential reactions to form complex selenide compounds has been developed. The C(O)-Se bond in selenoates is successfully cleaved, and various kinds of α-carbonyl selanes were synthesized in decent to excellent yields. The reaction has good functional group tolerance and broad substrate scope.