Exposure to persistent organochlorine compounds through fish consumption and the incidence of osteoporotic fractures
Exposure to persistent organochlorine compounds through fish consumption and the incidence of osteoporotic fractures
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DOI：
10.5271/sjweh.762
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发表时间：
2004-02-01
影响因子：
6.3
通讯作者：
Hagmar, L
中科院分区：
文献类型：
--
作者：
Wallin, E;Rylander, L;Hagmar, L
目的动物实验表明，持久性有机氯化合物（POC）损害正常的骨代谢，导致骨脆性增加。这些发现可能对接触POC的人群产生健康影响。本研究的目的是评估POC污染的鱼对瑞典渔民和他们的wifes.Methods自报骨折发病率的影响，邮寄问卷发送到2096渔民和1602渔民的妻子从瑞典东（暴露）海岸和4584渔民和4217渔民的妻子从西（未暴露）海岸。自我报告的骨折，以及指定的当前鱼类消费和潜在的混杂因素的信息，进行了登记。应答率在50%至59%之间。非受访者和受访者的年龄分布几乎相同。髋关节、椎骨和腕关节骨折被归类为骨折。骨折的发病率为特定的骨骼位置的基础上分配的骨折和人年的风险，从25岁到骨折的时间或随访结束。然而，与每月最多吃一顿波罗的海脂肪鱼的东海岸妻子相比，每月吃一顿以上波罗的海脂肪鱼的东海岸妻子的骨折发生率增加（年龄调整的发病率比为1.68，95%置信区间为1.00-2.84）。没有这样的安全响应协会被发现为fisher.Conclusions本研究只支持最低限度的POC暴露通过污染的鱼和脊椎骨折的风险增加之间的关联。
Objectives Animal studies have shown that persistent organochlorine compounds (POC) impair normal bone metabolism and result in increased bone fragility. These findings may have health implications for POC-exposed human populations. The aim of the present study was to assess the impact of POC-contaminated fish on the self-reported fracture incidence of Swedish fishermen and their wives.Methods A postal questionnaire was sent to 2096 fishermen and 1602 fishermen's wives from the Swedish east (exposed) coast and 4584 fishermen and 4217 fishermen's wives from the west (unexposed) coast. Self-reported fractures, together with specified current fish consumption and information about potential confounders, were registered. The response rates varied between 50% and 59%. The age distributions of the nonrespondents and respondents were almost identical. Hip, vertebral, and wrist fractures were classified as osteoporotic. The fracture incidence rates for specific skeletal locations were based on allocated fractures and person-years under risk from the age of 25 years until the time of fracture or the end of follow-up.Results No differences in fracture incidence were observed between the east and west-coast cohorts. East-coast wives with more than one meal of fatty fish from the Baltic Sea per month had, however, an increased fracture incidence as compared with that of the east-coast wives who ate, at most, one such meal per month (age-adjusted incidence rate ratio 1.68, 95% confidence interval 1.00-2.84). No such exposure-response association was found for the fishermen.Conclusions The present study only minimally supports an association between POC exposure through contaminated fish and an increased risk of osteoporotic fractures.