Effect of subanesthetic concentration of enflurane and halothane on human behavior.
Effect of subanesthetic concentration of enflurane and halothane on human behavior.
复制标题
安氟烷和氟烷亚麻醉浓度对人类行为的影响。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
E. Eger
中科院分区：
文献类型：
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作者：
T. L. Cook;M. Smith;P. Winter;J. Starkweather;E. Eger
：10 名男性志愿者在给予 3 种水平的肺泡氟烷（0.05、0.1 和 0.2%）各一个半小时以及（在不同的场合）安氟烷（0.15、0.3 和 0.4%）各一个半小时之前、期间和之后执行 3 项任务。测试的氟烷浓度分别代表 MAC 值的 7%、13% 和 27%；安氟醚的 MAC 值分别为 9%、18% 和 24%。这些任务包括选择反应时间测试、数字跨度测试和普渡大学钉板组装测试。志愿者还接受了单词对和图片的健忘症测试。在任一药剂的最低浓度下，均未检测到对精神功能的影响或仅有轻微影响。在较高浓度下，两种药物都会损害功能，表现为反应时间增加、记住数字的能力下降以及组装简单结构阵列的能力下降。氟烷的 MAC 失忆症为单词对而非图片失忆症，安氟烷的 MAC 失忆症为 18%。停止麻醉后半小时内所有测试分数均恢复至对照水平。我们的研究结果表明，亚麻醉但微量水平的安氟烷或氟烷会损害精神表现和手的灵活性并产生健忘症。所需的麻醉水平远远超过手术室人员所经历的水平。然而，在长时间麻醉后的患者中，这种水平可能会持续几个小时。
: Ten male volunteers performed 3 tasks before, during, and following administration of 3 levels of alveolar halothane (0.05, 0.1, and 0.2%) for one-half hour each and (on a separate occasion) enflurane (0.15, 0.3, and 0.4%) for one-half hour each. The concentrations of halothane tested representing 7, 13, and 27% of MAC values, respectively; those of enflurane were 9, 18, and 24% of MAC. The tasks were a choice-reaction time test, a digit span test, and a Purdue Pegboard Assembly test. Volunteers also were tested for amnesia with word pairs and a picture. No effects or only slight effects on mental function could be detected at the lowest concentrations of either agent. At higher concentrations both agents impaired function, as indicated by an increase in reaction time, decreased ability to remember numbers, and decreased ability to assemble a simple structural array. Amnesia for word pairs but not pictures occurred at 27% of MAC for halothane and 18% of MAC for enflurane. All test scores reverted to control levels within one-half hour after discontinuing the anesthetic. Our results indicate that subanesthetic but not trace levels of enflurane or halothane can impair mental performance and manual dexterity and produce amnesia. The levels of anesthetic required far exceed those experienced by operating room personnel. However, such levels might be found for several hours in patients following prolonged anesthesia.