Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma by placing a temporary catheter via the subclavian route
Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma by placing a temporary catheter via the subclavian route
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DOI：
10.1080/02841850701408210
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发表时间：
2007-01-01
期刊：
影响因子：
1.3
通讯作者：
Pan, Huay-Ben
中科院分区：
文献类型：
--
作者：
Liang, Huei-Lung;Huang, Jer-Shyung;Pan, Huay-Ben
Background: A permanent reservoir implantation is considered mandatory for hepatic arterial infusion chemotherapy ( HAIC) of hepatocellular carcinoma ( HCC). Since treatment sessions of HAIC may be limited for these end- staged patients, a simple alternative technique for this treatment is desirable. Purpose: To evaluate the feasibility of placing a temporary catheter for HAIC in advanced HCC patients. Material and Methods: 25 advanced HCC patients underwent HAIC with drugs delivered from a temporary catheter which was placed percutaneously by puncturing the left subclavian artery under ultrasound guidance. A course of chemotherapy consisted of five consecutive daily infusions of 5- fluorouracil, cisplatin, mitomycin C, and leucovorin. The catheter was removed on the 6th day. Therapy was repeated every 4 - 6 weeks with maximal number of courses of up to six. The total courses of HAIC in each patient, the catheter- placed- related complications, tumor response rate, and median survival of the patients were registered. Results: A total of 77 courses of HAIC were performed with 100% technical success of catheter placement ( 1 - 6 courses in each patient, average 3.1 courses). The overall response rate was 20%, with complete response in two patients and partial response in three patients. Eleven ( 55%) of the 20 non- responders died within 5 months ( mean HAIC, two courses). None of the patients experienced complications such as catheter occlusion, hepatic arterial thrombosis, cerebral infarction, or local infection. Conclusion: With fewer catheter- related complications, HAIC by temporary catheter placement via subclavian puncture could be a treatment option.
