Suboptimal nutrition in utero causes DNA damage and accelerated aging of the female reproductive tract
Suboptimal nutrition in utero causes DNA damage and accelerated aging of the female reproductive tract
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DOI：
10.1096/fj.13-234484
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发表时间：
2013-10-01
期刊：
影响因子：
4.8
通讯作者：
Ozanne, Susan E.
中科院分区：
文献类型：
--
作者：
Aiken, Catherine E.;Tarry-Adkins, Jane L.;Ozanne, Susan E.
生命早期暴露于不利环境可导致后代出现各种代谢和心血管疾病。我们推测，女性生殖功能也可能受到影响，随后影响生育能力。我们使用了一个已建立的母体低蛋白模型，其中动物出生时很小，但通过哺乳对照喂养的母鼠（恢复的后代）进行快速的产后追赶生长。在3月龄和6月龄时评估生殖道组织中的氧化应激和细胞衰老标志物。康复组仔鼠出生体重低于对照组（P
Early life exposure to adverse environments can lead to a variety of metabolic and cardiovascular diseases in offspring. We hypothesize that female reproductive function may also be affected, with subsequent implications for fertility. We used an established maternal low-protein model where animals are born small but undergo rapid postnatal catch-up growth by suckling a control-fed dam (recuperated offspring). Markers of oxidative stress and cellular aging in reproductive tract tissues were assessed at 3 and 6 mo of age. Recuperated offspring had lower birth weight than controls (P