Metal-free photocatalyzed aerobic oxidative Csp3-H functionalization of glycine derivatives: one-step generation of quinoline-fused lactones
Metal-free photocatalyzed aerobic oxidative Csp3-H functionalization of glycine derivatives: one-step generation of quinoline-fused lactones
复制标题
甘氨酸衍生物的无金属光催化有氧氧化C-sp(3)-H官能化：一步生成喹啉稠合内酯
DOI：
10.1039/c8ob00240a
复制
发表时间：
2018-05-28
影响因子：
3.2
通讯作者：
Li, Ying
中科院分区：
文献类型：
--
作者：
He, Youxiang;Yan, Baorun;Li, Ying
本发明公开了一种甘氨酸衍生物合成2，3-二氢呋喃的无金属有氧氧化脱氢偶联/环化串联反应。该过程涉及有机染料介导的光氧化还原催化和酸催化的协同性能。这一反应提供了一系列有价值的喹啉稠合内酯在室温和空气气氛下的快速和简便的获取途径。此外，该反应可在20 mm ol的范围内进行，且不会明显降低产率。
A metal-free aerobic oxidative dehydrogenative coupling/annulation tandem reaction of glycine derivatives to 2,3-dihydrofuran is disclosed. This process involves the synergistic performance of organic-dye-mediated photoredox catalysis and acid catalysis. This reaction provides rapid and facile access to a series of valuable quinoline-fused lactones at room temperature under an air atmosphere. Moreover, the reaction could be performed on a 20 mmol scale, without obvious reduction of the yield.