Socioeconomic Status and the Gut Microbiome: A TwinsUK Cohort Study
Socioeconomic Status and the Gut Microbiome: A TwinsUK Cohort Study
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DOI：
10.3390/microorganisms7010017
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发表时间：
2019-01-01
期刊：
影响因子：
4.5
通讯作者：
Steves, Claire J.
中科院分区：
文献类型：
--
作者：
Bowyer, Ruth C. E.;Jackson, Matthew A.;Steves, Claire J.
在健康和死亡率方面的社会经济不平等是公认的，但对这些关联背后的生物机制了解较少。与此同时，肠道微生物组正在成为人类健康的潜在重要决定因素，但对其更广泛的环境和社会决定因素知之甚少。我们在一个特征良好的双胞胎队列中测试了肠道微生物群组成与个人和地区社会经济因素之间的关联。在这项研究中，来自双胞胎登记处TwinsUK的1672名健康志愿者至少有一项社会经济指标的数据，现有的粪便16 S rRNA微生物群数据以及所有考虑的协变量。与社会经济地位（SES）的关联对于调整微生物组的已知健康相关性是稳健的;相反，这些健康-微生物组关联随着SES的调整而部分减弱。IMD（多重延迟指数）不一致的双胞胎通过成分差异的测量显示出显著差异，这表明双胞胎IMD的差异越大，其微生物群的差异就越大。未来的研究应该探索SES如何影响肠道微生物群的组成，以及它作为SES相关差异的介导者的潜在作用。
Socioeconomic inequalities in health and mortality are well established, but the biological mechanisms underlying these associations are less understood. In parallel, the gut microbiome is emerging as a potentially important determinant of human health, but little is known about its broader environmental and social determinants. We test the association between gut microbiota composition and individual- and area-level socioeconomic factors in a well-characterized twin cohort. In this study, 1672 healthy volunteers from twin registry TwinsUK had data available for at least one socioeconomic measure, existing fecal 16S rRNA microbiota data, and all considered co-variables. Associations with socioeconomic status (SES) were robust to adjustment for known health correlates of the microbiome; conversely, these health-microbiome associations partially attenuated with adjustment for SES. Twins discordant for IMD (Index of Multiple Deprivation) were shown to significantly differ by measures of compositional dissimilarity, with suggestion the greater the difference in twin pair IMD, the greater the dissimilarity of their microbiota. Future research should explore how SES might influence the composition of the gut microbiota and its potential role as a mediator of differences associated with SES.