Clobetasol propionate 0.05% under occlusion for alopecia areata: Clinical effect and influence on intraocular pressure
Clobetasol propionate 0.05% under occlusion for alopecia areata: Clinical effect and influence on intraocular pressure
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氯倍他索%20丙酸%200.05%%20下%20闭塞%20用于%20脱发%20面积:%20临床%20效果%20和%20影响%20上%20眼内%20压力
DOI：
10.1111/ajd.13479
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发表时间：
2021
影响因子：
2
通讯作者：
Katoh Norito
中科院分区：
文献类型：
--
作者：
Nomiyama Tomoko;Katoh Norito
已知局部皮质类固醇对斑秃的治疗有效，但对眼内压的潜在影响是一个问题。本回顾性研究的目的是评价0.05%丙酸氯倍他索在封闭条件下对活动期斑秃患者的疗效，并检查对眼压的影响。我们还希望了解减少氯倍他索的应用频率是否会增加眼内压方面的安全性。在本研究中使用的每周9.8 g或更低剂量下，不太可能发生局部皮质类固醇引起的眼内压升高;然而，认为治疗开始时的眼科检查对于识别潜伏性青光眼患者是值得的。
Topical corticosteroids are known to be effective in the treatment of alopecia areata, but the potential effects on intraocular pressure are a concern. The purpose of this retrospective study is to evaluate the effect of clobetasol propionate 0.05% under occlusion on patients with active phase alopecia areata and to examine the effects on intraocular pressure. We also wished to see if reducing the frequency of application of clobetasol increased the safety with respect to intraocular pressure. Elevation of intraocular pressure due to topical corticosteroids is unlikely to occur at the dose of 9.8 g or less per week used in this study; however, ophthalmologic examination at the start of treatment was thought to be worthwhile in identifying patients with latent glaucoma.