Spinal vasopressin alleviates formalin-induced nociception by enhancing GABA(A) receptor function in mice
Spinal vasopressin alleviates formalin-induced nociception by enhancing GABA(A) receptor function in mice
复制标题
脊髓加压素通过增强小鼠 GABA(A) 受体功能减轻福尔马林诱导的伤害感受
DOI：
10.1016/j.neulet.2015.03.023
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发表时间：
2015
影响因子：
2.5
通讯作者：
Hu Wang-Ping
中科院分区：
文献类型：
--
作者：
Peng Fang;Qu Zu-Wei;Qiu Chun-Yu;Liao Min;Hu Wang-Ping
Arginine vasopressin (AVP) plays a regulatory role in nociception. Intrathecal administration of AVP displays an antinociceptive effect. However, little is understood about the mechanism underlying spinal AVP analgesia. Here, we have found that spinal AVP dose dependently reduced the second, but not first, phase of formalin-induced spontaneous nociception in mice. The AVP analgesia was completely blocked by intrathecal injected SR 49059, a vasopressin-1A (V1A) receptor antagonist. However, spinal AVP failed to exert its antinociceptive effect on the second phase formalin-induced spontaneous nociception in V1Areceptor knock-out (V1A-/-) mice. The AVP analgesia was also reversed by bicuculline, a GABAAreceptor antagonist. Moreover, AVP potentiated GABA-activated currents in dorsal root ganglion neurons from wild-type littermates, but not from V1A-/- mice. Our results may reveal a novel spinal mechanism of AVP analgesia by enhancing the GABAAreceptor function in the spinal cord through V1Areceptors.
