Incidence of zidovudine-resistant human immunodeficiency virus isolated from patients before, during, and after therapy.
Incidence of zidovudine-resistant human immunodeficiency virus isolated from patients before, during, and after therapy.
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治疗前、治疗期间和治疗后从患者体内分离出的齐多夫定耐药性人类免疫缺陷病毒的发病率。
DOI：
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发表时间：
1992
影响因子：
6.4
通讯作者：
C. Birch
中科院分区：
文献类型：
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作者：
S. Land;Catherine H. McGavin;Ron Lucas;C. Birch
检测了237例人类免疫缺陷病毒(HIV)患者用药前、中、后分离的372株HIV对齐多夫定的敏感性。在36个月的治疗后，大多数患者(93%)分离出对-gt；0.5微克/毫升(1.87微米)齐多夫定具有耐药性的病毒。从15名已经结束抗逆转录病毒治疗但之前有耐药病毒的患者中分离出5例对齐多夫定敏感的病毒。治疗结束后敏感病毒的出现似乎受到治疗时间和停药时间的影响。耐药病毒患者在治疗开始时往往有低CD4细胞计数和艾滋病毒抗原血症，这表明这两个因素在耐药性的发展中很重要。
The zidovudine sensitivity of 372 isolates of human immunodeficiency virus (HIV) obtained from 237 patients before, during, and after treatment with zidovudine was examined. Virus resistant to > 0.5 micrograms/mL (1.87 microM) zidovudine was isolated from most patients (93%) after 36 months of therapy. Zidovudine-sensitive virus was isolated from 5 of 15 patients who had ended antiretroviral therapy but had previously shed resistant virus. The emergence of sensitive virus after end of therapy appeared to be influenced by both the duration of treatment and the time off drug. Patients with resistant virus tended to have low CD4 cell counts and HIV antigenemia at the commencement of therapy, suggesting that these two factors are important in the development of drug resistance.
影响因子：
158.5
作者：
HO, DD;MOUDGIL, T;ALAM, M
通讯作者：
ALAM, M
影响因子：
56.9
作者：
LARDER, BA;DARBY, G;RICHMAN, DD
通讯作者：
RICHMAN, DD
疾病阶段和药物剂量对人类免疫缺陷病毒分离株齐多夫定敏感性的影响。
DOI：
--
发表时间：
1990
期刊：
Journal of acquired immune deficiency syndromes
影响因子：
--
作者：
Richman,DD;Grimes,JM;Lagakos,SW
通讯作者：
Lagakos,SW