Heterogeneity in the composition of marijuana seized in California
Heterogeneity in the composition of marijuana seized in California
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DOI：
10.1016/j.drugalcdep.2010.11.031
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发表时间：
2011-08-01
影响因子：
4.2
通讯作者：
Pacula, Rosalie Liccardo
中科院分区：
文献类型：
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作者：
Burgdorf, James Richard;Kilmer, Beau;Pacula, Rosalie Liccardo
背景：大麻素含有多种大麻素。最受关注的是delta-9-tetrahydrocannabinol（THC），它会产生欣快感，在某些情况下会产生焦虑和恐慌反应。研究表明，另一种大麻素，大麻二酚（CBD），可能会抵消其中的一些影响。因此，有越来越多的兴趣在健康后果的四氢大麻酚与CBD的比例为marijuan.Methods：使用数据从超过5000大麻样本在加州从1996年至2008年，我们研究的变化，中位数四氢大麻酚水平，中位数CBD水平，和中位数四氢大麻酚：CBD的比例。结果：中位数四氢大麻酚水平和中位数四氢大麻酚：CBD的比例有显着增加癫痫发作在加州，特别是墨西哥边境以北。关于THC：CBD比例的后果的研究应该继续，特别是当更多的注意力集中在思考如何规范大麻用于医疗和娱乐用途时。研究人员在评估大麻对健康的影响时，还应该考虑到大麻的化学成分缺乏统一性。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Background: Marijuana contains multiple cannabinoids. Most attention is given to delta-9-tetrahydrocannabinol (THC) which produces euphoria and in some cases anxiety and panic reactions. Research suggests that another cannabinoid, cannabidiol (CBD), may offset some of these effects. Thus, there is growing interest in the health consequences of the THC to CBD ratio for marijuana.Methods: Using data from over 5000 marijuana samples in California from 1996 to 2008, we examine changes in the median THC-level, median CBD-level, and median THC:CBD-ratio.Results: The median THC-level and median THC:CBD-ratio have dramatically increased for seizures in California, particularly north of the Mexican border.Conclusion: Research on the consequences of the THC:CBD ratio should continue, especially as more attention is devoted to thinking about how to regulate marijuana for medical and recreational use. Researchers should also consider the lack of uniformity in the chemical composition of marijuana when evaluating its health effects. (C) 2011 Elsevier Ireland Ltd. All rights reserved.