Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy
Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy
复制标题
血管损伤标志物与接受抑制性抗逆转录病毒治疗的艾滋病毒感染者认知障碍相关
DOI：
10.1097/qad.0000000000003675
复制
发表时间：
2023-11-15
期刊：
影响因子：
3.8
通讯作者：
Gabuzda, Dana
中科院分区：
文献类型：
--
作者：
Guha, Debjani;Misra, Vikas;Gabuzda, Dana
Objective: Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) remain prevalent despite viral suppression on antiretroviral therapy (ART). Vascular disease contributes to HAND, but peripheral markers that distinguish vascular cognitive impairment (VCI) from HIV-related etiologies remain unclear.Design: Cross-sectional study of vascular injury, inflammation, and central nervous system (CNS) injury markers in relation to HAND.Methods: Vascular injury (VCAM-1, ICAM-1, CRP), inflammation (IFN-gamma, IL-1 beta, IL-6, IL-8, IL-15, IP-10, MCP-1, VEGF-A), and CNS injury (NFL, total Tau, GFAP, YKL-40) markers were measured in plasma and CSF from 248 individuals (143 HIV+ on suppressive ART and 105 HIV- controls).Results: Median age was 53 years, median CD4+ cell count, and duration of HIV infection were 505 cells/mu l and 16 years, respectively. Vascular injury, inflammation, and CNS injury markers were increased in HIV+ compared with HIV- individuals (P < 0.05). HAND was associated with increased plasma VCAM-1, ICAM-1, and YKL-40 (P
