Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone
Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone
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DOI：
10.1111/j.0022-202x.2004.23545.x
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发表时间：
2005-01-01
影响因子：
6.5
通讯作者：
Labrie, F
中科院分区：
文献类型：
--
作者：
Azzi, L;El-Alfy, M;Labrie, F
性类固醇在皮肤形态和生理中起着重要作用。为了评价性类固醇的具体作用，测量了完整和性腺切除（GDX）的雄性和雌性小鼠以及用17 β-雌二醇（E-2）、双氢睾酮（DHT）或其前体脱氢表雄酮（DHEA）治疗3周的GDX动物的每个皮肤层的厚度。形态学分析表明，完整的男性背部皮肤厚于女性，而表皮和皮下组织厚于女性。GDX后，表皮厚度仅在雌性中减少，变得与完整的雄性相似。E-2处理后，两种性别GDX动物的表皮厚度增加至与完整雌性动物相似的值，而仅在DHEA处理后的雌性动物中观察到增加。DHEA和DHT都增加了皮肤厚度，而E-2，DHT和DHEA显着降低GDX动物的皮下厚度的两种性别。在所有条件下，雌性的下皮层仍然较厚。GDX触发毛发从休止期到生长期的快速生长，女性的毛干直径较粗。这些数据表明，DHT，E-2和DHEA对不同的皮肤层和附属物产生特定的影响。
Sex steroids play an important role in skin morphology and physiology. To evaluate the specific effects of sex steroids, the thickness of each skin layer was measured in intact and gonadectomized (GDX) male and female mice, as well as in GDX animals treated for 3 wk with 17beta-estradiol (E-2), dihydrotestosterone (DHT), or their precursor dehydroepiandrosterone (DHEA). Morphological analysis shows that the dorsal skin of intact male is thicker than in the female, whereas the epidermis and hypodermis are thicker in the female. After GDX, epidermal thickness decreases only in the female to become similar to that of the intact male. Epidermal thickness in GDX animals of both sexes increases after E-2 treatment to a value similar to that of intact females, whereas an increase is observed only in females after DHEA treatment. Both DHEA and DHT increased dermal thickness whereas E-2, DHT, and DHEA markedly reduced hypodermal thickness in GDX animals of both sexes. Under all conditions, the hypodermis remains thicker in females. GDX triggers a rapid hair growth from telogen to anagen with a thicker hair shaft diameter in females. This data shows that DHT, E-2, and DHEA exert specific effects on the different skin layers and appendages.