Enantioselective oxidation of racemic lactic acid to D-lactic acid and pyruvic acid by Pseudomonas stutzeri SDM
Enantioselective oxidation of racemic lactic acid to D-lactic acid and pyruvic acid by Pseudomonas stutzeri SDM
复制标题
施氏假单胞菌 SDM 将外消旋乳酸对映选择性氧化为 D-乳酸和丙酮酸。
DOI：
10.1016/j.biortech.2008.09.053
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发表时间：
2009-03-01
影响因子：
11.4
通讯作者：
Xu, Ping
中科院分区：
文献类型：
--
作者：
Gao, Chao;Qiu, Jianhua;Xu, Ping
D-乳酸和丙酮酸是两个重要的构筑中间体。外消旋乳酸生物转化法生产D-乳酸和丙酮酸具有重要的经济意义。由9g斯氏假单胞菌L(-1)制备的生物催化剂能在10h内催化45.00g L(-1)DL-乳酸生成25.23g L(-1)D-乳酸和19.70g L(-1)丙酮酸，并通过简单的离子交换将D-乳酸和丙酮酸从生物转化系统中分离出来。外消旋乳酸对映体选择性氧化联产D-乳酸和丙酮酸在技术上是可行的。(C)2008爱思唯尔有限公司。保留所有权利。
D-Lactic acid and pyruvic acid are two important building block intermediates. Production of D-lactic acid and pyruvic acid from racemic lactic acid by biotransformation is economically interesting. Biocatalyst prepared from 9 g dry cell wt l(-1) of Pseudomonas stutzeri SDM could catalyze 45.00 g l(-1) DL-lactic acid into 25.23 g l(-1) D-lactic acid and 19.70 g l(-1) pyruvic acid in 10 h. Using a simple ion exchange process, D-lactic acid and pyruvic acid were effectively separated from the biotransformation system. Co-production Of D-lactic acid and pyruvic acid by enantioselective oxidation of racemic lactic acid is technically feasible. (C) 2008 Elsevier Ltd. All rights reserved.