Correlates of bone mineral density in men of African ancestry: The Tobago Bone Health Study
Correlates of bone mineral density in men of African ancestry: The Tobago Bone Health Study
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DOI：
10.1007/s00198-007-0450-9
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发表时间：
2008-02-01
影响因子：
4
通讯作者：
Zmuda, J. M.
中科院分区：
文献类型：
--
作者：
Hill, D. D.;Cauley, J. A.;Zmuda, J. M.
在对西非血统男性的横断面分析中，研究了骨密度的相关因素。在多元线性回归模型中，在全髋关节和股骨颈亚区测量的骨密度与年龄、人体测量、生活方式和医学因素相关。这些模型分别解释了25-27%的髋关节和股骨颈骨密度变异性和13%的估计体积骨密度变异性。目的探讨西非血统男性骨密度（BMD）的相关因素。方法从加勒比海多巴哥岛招募年龄在40 ~ 93岁的男性2501人。参与者完成了问卷调查和身体检查。我们使用DXA测量髋部骨密度和身体成分。体积骨密度以骨矿物质表观密度（BMAD）估算。结果与美国非西班牙裔黑人和白人男性相比，非洲裔加勒比男性的骨密度分别高出10%和20%。在多元线性回归模型中，较大的瘦质量、在渔船或农场工作的历史、频繁步行和自我报告的糖尿病与较高的骨密度显著相关。脂肪量、农业史和自我报告的高血压也与较高的BMAD有关。年龄较大、非洲混血血统和骨折史与较低的骨密度和骨密度有关。瘦体重分别解释了全髋、股骨颈和BMAD骨密度差异的20%、18%和6%。结论：非裔加勒比地区男性的骨密度在人口水平上是最高的。瘦体重是唯一最重要的关联。BMD/BMAD的变异也可以用年龄、非洲混血血统、人体测量、生活方式和医学因素来解释。
Correlates of BMD were examined in a cross-sectional analysis of men of West African ancestry. BMD, measured at the total hip and the femoral neck subregion, was associated with age, anthropometric, lifestyle, and medical factors in multiple linear regression models. These models explained 25-27% of the variability in total hip and femoral neck BMD, respectively, and 13% of the variability in estimated volumetric BMD.Objective To examine the correlates of bone mineral density (BMD) in men of West African ancestry.Methods Two thousand five hundred and one men aged 40 to 93 years were recruited from the Caribbean Island of Tobago. Participants completed a questionnaire and physical examination. We measured hip BMD and body composition, using DXA. Volumetric BMD was estimated as bone mineral apparent density (BMAD).Results BMD was 10% and 20% higher in African Caribbean males compared to U.S. non-Hispanic black and white males, respectively. In multiple linear regression models, greater lean mass, history of working on a fishing boat or on a farm, frequent walking, and self-reported diabetes were significantly associated with higher BMD. Fat mass, history of farming, and self-reported hypertension were also associated with higher BMAD. Older age, mixed African ancestry, and history of a fracture were associated with lower BMD and BMAD. Lean body mass explained 20%, 18% and 6% of the variance in BMD at the total hip, femoral neck and BMAD, respectively.Conclusions African Caribbean males have the highest BMD on a population level ever reported. Lean mass was the single most important correlate. Variability in BMD/BMAD was also explained by age, mixed African ancestry, anthropometric, lifestyle, and medical factors.